Medical Research Tech III

Major/Essential Functions

Conduct western blotting, ELISA, and immunoprecipitation assays to study drug–target engagement and pathway inhibition. Perform RNA/protein isolation, qRT-PCR, cloning, mutagenesis, and transient/stable gene manipulation in cancer cell lines. Culture 2D and 3D cancer spheroid models, including lentiviral/siRNA-mediated knockdowns and drug synergy studies.
Conduct immunofluorescence staining and digital imaging using confocal microscopy to assess subcellular localization and phenotypic markers.
Perform live-cell imaging and apoptotic/mitotic readouts (Annexin V, TUNEL, Ki-67, H2AX, etc.).
Assist in establishing xenograft, syngeneic, and orthotopic tumor models for breast, ovarian, pancreatic, and glioma studies. Conduct drug administration (IP/SC/PO), tumor measurement, survival tracking, necropsy, tissue collection, and histological preparation. Support pharmacokinetic/pharmacodynamic (PK/PD) sample processing and biomarker evaluation.
Maintain cell line inventory, animal colony genotyping, reagent preparation, and equipment calibration. Guide junior lab members in standard operating procedures and contribute to manuscript and figure preparation. Uphold lab safety, IACUC, and biosafety protocols.
Remains current with all licensure, certifications and mandatory compliances and trainings required of this position.
Adhere to all policies, procedures and practices (Regents Rules, TTUS, HSECEP OPs, etc.).
Personally demonstrate, display, and act in accordance with TTUHSCEP’s values (Service, Respect, Accountability, Integrity, Advancement and Teamwork). Actively promote and encourage staff across the institution.
Performs all other duties as assigned.

Required Qualifications

Bachelor's degree in one of the sciences, or equivalent combination (4 years) of job-related experience and college education.
Experience may be substituted for college education on a year for year basis.

Preferred Qualifications

Laboratory experience, ideally in a translational oncology or therapeutic development setting.
Proficiency in mammalian cell culture, western blotting, nucleic acid analysis, and fluorescence microscopy.
Willingness and eligibility to work with mouse tumor models and BSL-2 viral vectors.
Experience with targeted therapy or drug resistance models (e.g., GR antagonists, Midkine inhibitors, LIFR pathway).
Familiarity with survival surgery for PDX or syngeneic tumor implantation and IVIS/bioluminescence imaging.
Skilled in scientific software (ImageJ/Fiji, GraphPad Prism, Adobe Illustrator, FlowJo).
Strong organizational and data management skills with attention to reproducibility and rigor.

EEO Statement

All qualified applicants will be considered for employment without regard to sex, race, color, national origin, religion, age, disability, protected veteran status, or genetic information.

Jeanne Clery Act

The Jeanne Clery Disclosure of Campus Security Policy and Campus Crime Statistics Act is a federal statute requiring colleges and universities participating in federal financial aid programs to maintain and disclose campus crime statistics and security information. By October 1 of each year, institutions must publish and distribute their Annual Campus Security Policy & Crime Statistics Report (ASR) to current and prospective students and employees. You can locate this report through our website at: https://www.ttuhsc.edu/emergency/clery-report.aspx

Does this position work in a research laboratory?

Yes

Are select agents used in this laboratory?

Yes

Required Attachments

Cover Letter, Resume / CV, Transcript

Job Type

Full Time

Pay Basis

Hourly

Minimum Hire Rate

Compensation is commensurate upon the qualifications

Pay Statement

Compensation is commensurate upon the qualifications of the individual selected and budgetary guidelines of the hiring department, as well as, the institutional pay plan. For additional information, please reference the institutional pay plan on the Human Resources webpage.

Travel Required

None

Shift

Day

Grant Funded?

Yes

Job Group

Research Technicians