Scientist – Proteomics & Mass Spectrometry

Job Title: Scientist – Proteomics & Mass Spectrometry

Location: Collegeville, PA

Employment Type: Full-Time

About the Role

The Molecular Modalities Discovery group is seeking a highly motivated scientist with expertise in proteomics and informatics to support capability development in the mass spectrometry (MS)-omics space , with a particular focus on oligonucleotides and single-point mutations. This is a bench-focused role requiring hands-on experience in biological mass spectrometry workflows.

Key Responsibilities

• Perform biological mass spectrometry workflows with a primary focus on proteomics .
• Support small molecule discovery , including identification and progression of molecules that interact with drug targets.
• Execute sample preparation steps, including:
• Handling cryogenically preserved cells (not chemically fixed).
• Buffer treatment for cell lysis and protein extraction.
• Enrichment steps (e.g., amino precipitation).
• Protein digestion and peptide processing.
• Reconstitution and loading samples onto MS tips for automated analysis.
• Learn and apply core workflows for MS-based proteomics.
• Collaborate with partners for occasional live-cell handling.
• Maintain accurate documentation and adhere to standard operating procedures.

Qualifications

• Bachelor’s degree in Biology, Biochemistry, or related field (advanced degree preferred).
• Hands-on experience with mass spectrometry in a biological context .
• Strong understanding of proteomics MS workflows and sample preparation techniques.
• Familiarity with informatics tools for data analysis is a plus.
• Ability to work independently at the bench and troubleshoot technical challenges.

Preferred Skills

• Background in biology and handling biological materials.
• Knowledge of oligos analysis and mutation detection.
• Experience with MS automation

Compensation:

$45-70/hr

Exact compensation may vary based on several factors, including skills, experience, and education.

Benefit packages for this role will start on the 31st day of employment and include medical, dental, and vision insurance, as well as HSA, FSA, and DCFSA account options, and 401k retirement account access with employer matching. Employees in this role are also entitled to paid sick leave and/or other paid time off as provided by applicable law.