Qureos Mentor

Arrowhead Pharmaceuticals

<div><div>Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI &amp; San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.</div>
The Position

Arrowhead is seeking a highly motivated biologist to join our growing CNS in vivo team within the Research Department at our San Diego site. The successful candidate will be joining a team dedicated to discovering, developing and translating novel drug targets.

Responsibilities
<ul>
<li>Perform in vivo studies and ex vivo analysis to facilitate drug discovery and development in various diseases</li>
<li>Establish new preclinical animal disease models</li>
<li>Perform animal behavior studies as needed</li>
<li>Coordinate processes across departments and with outside vendors to enable efficient study execution and data generation</li>
<li>Read and apply relevant scientific literature to projects to troubleshoot and solve problems</li>
<li>Present research findings to project teams and prepare technical reports</li>
<li>Maintain a high level of productivity in the lab and perform critical experiments</li>
</ul>
Requirements:
<ul><li>BS and/or MS in biology related field</li>
<li>Extensive experience with small animal handling</li>
<li><ul><li>Experience with sample collection / tissue collection</li>
</ul></li><li>Excellent record keeping and experience in data analysis, graphing and presentation</li>
<li>Ability to work independently and to handle multiple projects and deadlines</li>
<li>Demonstrated innovation, creativity and resilience in problem solving</li>
<li>Excellent oral and written communication skills</li>
<li>Self-motivated team player with the ability to thrive in a fast paced, multi-disciplinary, matrixed environment</li>
</ul>
Preferred:
<ul>
<li>Experience with CNS surgeries and/or drug administration locally in CNS</li>
<li>Experiences with animal dose administration and surgical procedures</li>
<li>Preclinical disease model development in the context of drug discovery</li></ul><div> 
Arrowhead provides competitive salaries and an excellent benefit package.

All applicants must have authorization to work in the US for a company.

California Applicant Privacy Policy</div></div>

Associate Scientist I, In Vivo Research

<div>
 Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead&rsquo;s RNAi-based therapeutics leverage this natural pathway of gene silencing.
 
 
 Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
 
 
 Arrowhead&rsquo;s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI &amp; San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
 
 
 
 The Position
 
 
 
 This position will involve assisting in the synthesis and subsequent purification steps of large scale oligonucleotides. The operator must comply with GLP/GMP protocols and be able to follow all association SOPs and work instructions when performing and documenting operations.
 
 
 
 Responsibilities
 
 
 
 <ul>
 <li>
 Prepare batch records, SOPs, and work instructions to detail
 </li>
 <li>
 Document alloperations in batch records and notebooks
 </li>
 <li>
 Experience in investigating and closing deviations
 </li>
 <li>
 Ability to identify, design, and implement process improvements
 </li>
 <li>
 Comply with GMP protocols
 </li>
 <li>
 Operate large scale oligonucleotide manufacturing equipment (i.e. oligonucleotide synthesizer, purification skid, tangential flow filtration system, lyophilizer, ChemGlass reactors, pH/conductivity meters, peristaltic pumps, )
 </li>
 <li>
 Lead and provide support to other chemists within the CMC group during synthesis and purification of oligonucleotides including:
 </li>
 <ul>
 <li>
 Reagent solution preparation
 </li>
 <li>
 Mobile phase preparation
 </li>
 <li>
 Column Packing
 </li>
 <li>
 Fraction collection
 </li>
 </ul>
 <li>
 Develop and optimize test methods for oligonucleotide/intermediate analysis via LCMS
 </li>
 <li>
 Assist in scale up/process development from small/mid-scale chemistry
 </li>
 <li>
 Contact vendors for purchasing manufacturing equipment/performing routine maintenance and repair, and assist with FATs for equipment as needed
 </li>
 <li>
 Maintain a clean work space
 </li>
 <li>
 Maintain safety by wearing required personal protective equipment
 </li>
 <li>
 Maintain safety by wearing required personal protective equipment
 </li>
 <li>
 Track and update raw material usage in D365 ERP software
 </li>
 <li>
 Act as production campaign lead
 </li>
 <li>
 Assist with new personnel training
 </li>
 <li>
 Address and resolve production challenges proactively, utilizing analytical and critical thinking skills
 
 
 </li>
 </ul>
 
 Requirements:
 
 
 
 <ul>
 <li>
 Bachelors degree in a scientific field
 </li>
 <li>
 5-10 years experience in a similar position
 </li>
 <li>
 Experience working in a GMP setting and controlled documentation
 </li>
 <li>
 Ability to move and lift up to 50 pounds
 </li>
 <li>
 Good verbal and written communication skills
 </li>
 <li>
 Ability to work in a team environment
 </li>
 <li>
 Ability to pay attention to detail
 
 
 </li>
 </ul>
 Wisconsin pay range
 
 
 $78,000&mdash;$90,000 USD
 
 
 Arrowhead provides competitive salaries and an excellent benefit package.
 
 
 All applicants must have authorization to work in the US for a company.
 
 
 California Applicant Privacy Policy
</div>

Associate Manufacturing Scientist

<div>
 Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead&rsquo;s RNAi-based therapeutics leverage this natural pathway of gene silencing.
 
 
 Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
 
 
 Arrowhead&rsquo;s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI &amp; San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
 
 
 
 The Position
 
 
 
 This position is part of the Analytical Development (AD) group within the CMC Manufacturing organization. The Sr. AD Scientist will support method development and validation activities for new drug substances and drug products. Responsibilities include testing to support process development, impurity characterization, and activities related to GLP toxicology and cGMP clinical trial materials. This role reports to AD management.
 
 
 
 Responsibilities
 
 
 
 <ul>
 <li>
 Know and adhere to Arrowhead Core Values, cGMP policies and procedures and relevant SOPs
 </li>
 <li>
 Provide accurate analytical results in support of new and on-going projects
 </li>
 <li>
 Work independently and with project teams to meet and lead project timelines and deliverables
 </li>
 <li>
 Provide leadership, technical guidance, and development to junior scientists
 </li>
 <li>
 Serve as Analytical Project Coordinator or Lead for on-going or new projects and take ownership of analytical requirements needed, including scheduling, prioritizing and coordinating analytical testing
 </li>
 <li>
 Prepare technical reports, presentations, SOPs, and policies and procedures
 </li>
 <li>
 Independently design and initiate development of analytical methods and improvement of existing ones, to support all stages of API (active pharmaceutical ingredient) and drug product development
 </li>
 <li>
 Apply advanced scientific principles, theories and concepts to a broad range of research problems and develop innovative solutions for analytical problems related to drug substances and/or drug products in compliance with appropriate Standard Operating Procedures (SOPs) and regulatory guidelines
 </li>
 <li>
 Develop specifications and test methods for raw materials, in-process and isolated intermediates, as well as drug products
 </li>
 <li>
 Design and execute non-routine experiments
 </li>
 <li>
 Analyze and interpret data/results and outcome of experiments and propose appropriate follow-up
 </li>
 <li>
 Write project documentation (Analytical test methods, developmental reports, validation reports, and protocols) of higher complexity
 </li>
 <li>
 Collaborate with other groups and activities necessary to ensure project deliverables are met
 </li>
 <li>
 Perform peer review of notebooks, protocols, and validation documentation
 </li>
 <li>
 Draft Out of Specification and Deviations documents
 </li>
 <li>
 Perform testing of test samples in support of API and drug development
 </li>
 <li>
 Calibrate, maintain, and troubleshoot all analytical equipment
 </li>
 <li>
 May perform release testing of raw materials, stability study samples, method validation, and method transfer activities for toxicology and clinical trial activities when needed
 </li>
 <li>
 Other duties as assigned
 
 
 </li>
 </ul>
 
 Requirements:
 
 
 
 <ul>
 <li>
 Ph.D. in Chemistry (or related field) with 0-5 years of relevant experience, M.S. in Chemistry (or related field) with at least 10 years of relevant experience, or B.S in Chemistry (or related field) with at least 14 years of relevant experience., UV/Vis, LC/MS, KF, etc.
 </li>
 <li>
 Expertise in method development and validations in support of drug substance and drug product development, and manufacture
 </li>
 <li>
 Skills and knowledge in handling, analyzing and characterizing chemicals, pharmaceuticals and related organic molecules
 </li>
 <li>
 Expertise with analytical instrumentation, and test methodology/validations
 </li>
 <li>
 Knowledgeable with data acquisition systems, and cGMP policies and practices
 </li>
 <li>
 Demonstrated experience with analytical instrumentation theory and practice as well as pharmaceutical drug substance and drug product development and processes
 </li>
 <li>
 Has a solid understanding of CMC regulatory requirements for pharmaceutical products
 </li>
 <li>
 Knowledgeable of cGMP, ICH, CDER requirements
 </li>
 <li>
 Understanding of basic theories and principles of synthetic organic chemistry
 </li>
 <li>
 Strong attention to detail
 </li>
 <li>
 Can perform tasks assigned with minimal supervision
 </li>
 <li>
 Works well with others and in a team environment
 </li>
 <li>
 Can be flexible with changing priorities
 
 
 </li>
 </ul>
 Wisconsin pay range
 
 
 $110,000&mdash;$130,000 USD
 
 
 Arrowhead provides competitive salaries and an excellent benefit package.
 
 
 All applicants must have authorization to work in the US for a company.
 
 
 California Applicant Privacy Policy
</div>

Scientist / Sr. Scientist, CMC Analytical Development

Join Arrowhead Pharmaceuticals and explore 3   exciting career opportunities. They're hiring for various roles with options for remote or on-site work. Apply today and become part of their innovative team.

Arrowhead Pharmaceuticals

ABOUT_COMPANY

Associate Scientist I, In Vivo Research

Associate Manufacturing Scientist

Scientist / Sr. Scientist, CMC Analytical Development