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Denali Therapeutics

<div>Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.<div><div><div><div>
We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.</div></div></div></div>
Denali Therapeutics Inc. is seeking a Senior Manager of Commercial Supply Planning to support upcoming Commercial product launch and establish scalable processes for global commercial supply operations. This role will develop and lead the execution of supply plans across our external Drug Substance and Drug Product manufacturing network while ensuring that SAP accurately reflects real-time activity within the commercial supply chain. The position reports to Head of Supply Chain Planning and plays a critical role in enabling launch readiness and post-launch execution.
Key Accountabilities/Core Job Responsibilities:<ul><li>
Develop and maintain a rolling production plan aligned with forecast, safety stock, and lot-sizing constraints.</li><li>
Convert demand forecasts into executable production and packaging plans with CMOs.</li><li>
Monitor and manage launch readiness, including DS/DP inventory targets, expiry windows, and campaign timing.</li><li>
Partner with QA, Manufacturing, and Regulatory to ensure supply strategy supports release, labeling, and distribution needs.</li><li>
Support Sales &amp; Operations Planning (S&amp;OP) process with capacity scenarios, risk assessments, and metrics</li><li>
Identify and escalate risks related to supply shortages, delays, or over-production.</li><li>
Manage Denali&rsquo;s Sales &amp; Operations Execution (S&amp;OE) process in conjunction with CMC Program Leader to ensure adherence to production plan across both internal and external stakeholders</li><li>
Create, manage, and monitor the end-to-end material procurement process including Purchase Requisitions, Purchase Orders, and Goods Receipts within SAP</li><li>
Reconcile SAP inventory positions with external batch and shipment data, flagging discrepancies and driving resolution.</li><li>
Track and input batch-level data such as shelf life, release dates, and sampling requirements, and destruction logs.</li></ul>
Qualifications/Skills:<ul><li>
5+ to 10 years in supply or production planning, preferably in biotech/pharma.</li><li>
Direct experience working with external manufacturing partners (CMOs/3PLs)</li><li>
Strong Excel and analytical skills.</li><li>
Proficient in ERP systems with hands-on experience in production planning, materials management, and inventory management modules (e.g., order creation, goods receipt, and batch tracking transactions).</li><li>
Strong understanding of external manufacturing (CMOs) and batch-based planning.</li><li>
Proven ability to manage multiple priorities, timelines, and data streams across functions.</li><li>
High proficiency in Excel (pivot tables, lookups, simple macros).</li></ul>
Preferred<ul><li>
Experience supporting a commercial product launch in a regulated industry</li><li>
Familiarity with GMP inventory practices and batch traceability.</li><li>
Comfortable navigating cross-functional discussions across Quality, Regulatory, and CMC</li></ul>
Why This Role Matters
This is a critical role within Denali&rsquo;s rapidly scaling supply chain team. You&rsquo;ll ensure supply readiness and system visibility during a high-impact product launch, helping build the foundation for Denali&rsquo;s global commercial supply capabilities.
Salary Range: $152,000.00 to $185,000.00 . Compensation for the role will depend on a number of factors, including a candidate&rsquo;s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers
This compensation and benefits information is based on Denali&rsquo;s good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali&rsquo;s good faith estimate as of the date of publication and may be modified in the future. 
Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.</div>

Senior Manager, Commercial Supply Planning

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Denali Therapeutics

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Senior Manager, Commercial Supply Planning