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Frederick National Laboratory for Cancer Research

<div>Small Lab Animal Research Specialist

Job ID: req4383 
Employee Type: exempt full-time 
Division: Laboratory Animal Science Program 
Facility: Frederick: Ft Detrick 
Location: PO Box B, Frederick, MD 21702 USA

The Frederick National Laboratory is operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases. 
 
Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.
PROGRAM DESCRIPTION

The Laboratory Animal Sciences Program (LASP) provides exceptional quality animal care and technical support services for animal research performed at the National Cancer Institute at the Frederick National Laboratory for Cancer Research. LASP executes this mission by providing a broad spectrum of state-of-the-art technologies and services focused on the design, generation, characterization, and application of genetically engineered and biological animal models of human disease. The Animal Research Technical Support (ARTS) team within LASP utilizes advanced methodologies to perform research into the development of new cancer models, targeted diagnostics, and cancer therapies.

KEY ROLES/RESPONSIBILITIES

As a Lab Animal Research Specialist, you will be working closely with a diverse team in a fast-paced environment on multiple basic and translational cancer research projects simultaneously. Types of studies include tumorigenesis, toxicity, PK/PD, cancer treatment and vaccine efficacy studies on xenograft/allograft, PDX, or genetically engineered mouse models. Responsibilities include working closely with senior technical staff on conducting parts of or entire in vivo portions of studies from start to finish, including organizing experiments, performing injections, recording and creating detailed study reports, and updates for the investigators. Lab Animal Research Specialists help coordinate and communicate study details and scheduling with other core facilities, team members, and management. Specific responsibilities include:
<ul>
<li>Performing rodent colony management and maintenance of real-time animal colony database (TOPAZ).</li>
<li>Following breeding strategies based on genotyping results.</li>
<li>Independently carrying out parts of or complete experimental studies under the guidance of senior staff.</li>
<li>Administration of experimental compounds and chemical carcinogens.</li>
<li>Performing injections via various routes including s.c., i.p., i.v., and oral gavage.</li>
<li>Monitoring phenotypes and treatment responses.</li>
<li>Performing detailed necropsy procedures to collect blood and tissues.</li>
<li>Collecting and recording tumor measurements and body weights utilizing electronic instruments and databases.</li>
<li>Working with potentially hazardous radiological, chemical, and biological materials.</li>
<li>This is a change-in facility.</li>
<li>Work schedule may include weekend and holiday hours.</li></ul>

BASIC QUALIFICATIONS

To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
<ul>
<li>Possession of Bachelor&rsquo;s degree in Life Sciences or Veterinary Technology from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) or Any combination of education and progressively responsible technical experience which qualifies the candidate to sit for the LATG Certification exam within 12 months of hire in lieu of degree. Will encourage achievement of LATG Certification, however this is not required. Foreign degrees must be evaluated for U.S. equivalency.</li>
<li>No work experience required with a Bachelor's degree.</li>
<li>Experience in management of genetically engineered mouse models.</li>
<li>Proficiency in performing rodent related techniques such as injections via various routes, blood and tissue collection.</li>
<li>Ability to work in a team and communicate with management in a demanding scientific environment.</li>
<li>Experience in rodent breeding colony management and associated procedures.</li>
<li>Experience in performing experimental procedures including injections and compound administration.</li>
<li>Experience working with various tumor models.</li>
<li>Ability to maintain precise, accurate records utilizing different software platforms.</li>
<li>Excellent time management and organization skills; ability to multi-task and work under time constraints.</li>
<li>Excellent written and oral communications skills.</li>
<li>Knowledge of standard operating procedures for animal facilities and ACUC guidelines.</li>
<li>Ability to lift up to 50 lbs. and to wear respiratory protection equipment if necessary.</li>
<li>Must be able to obtain and maintain a security clearance.</li>
</ul>
PREFERRED QUALIFICATIONS

Candidates with these desired skills will be given preferential consideration:
<ul><li>Experience with cancer treatment or vaccine studies in rodents.</li>
<li>Experience preparing medicated water and chemicals.</li>
<li>LAT certification and ability to pass LATG exam within 12 months of hire.</li>
</ul>
Job Hazards
<ul>
<li>This position is subject to atmospheric conditions that would require the usage of a respirator, requiring a medical clearance.</li>
<li>This position is subject to working with or have potential for exposure to 
animal(s) and/or animal material(s).</li>
<li>This position is subject to working with or have potential for exposure to 
infectious material, requiring medical clearance and immunizations.</li></ul> 

Commitment to Non-Discrimination 
All qualified applicants will receive consideration for employment without regard to sex, race, ethnicity, color, age, national origin, citizenship, religion, physical or mental disability, medical condition, genetic information, pregnancy, family structure, marital status, ancestry, domestic partner status, sexual orientation, gender identity or expression, veteran or military status, or any other basis prohibited by law. Leidos will also consider for employment qualified applicants with criminal histories consistent with relevant laws.

Pay and Benefits

Pay and benefits are fundamental to any career decision. That's why we craft compensation packages that reflect the importance of the work we do for our customers. Employment benefits include competitive compensation, Health and Wellness programs, Income Protection, Paid Leave and Retirement. More details are available here
46,900.00 - 80,500.00 USD
The posted pay range for this job is a general guideline and not a guarantee of compensation or salary. Additional factors considered in extending an offer include, but are not limited to, responsibilities of the job, education, experience, knowledge, skills, and abilities as well as internal equity, and alignment with market data.

The salary range posted is a full-time equivalent salary and will vary depending on scheduled hours for part time positions</div>

Small Lab Animal Research Specialist

<div>Research Associate II - ACVP

Job ID: req4377 
Employee Type: exempt full-time 
Division: AIDS &amp; Cancer Virus Program 
Facility: Frederick: Ft Detrick 
Location: PO Box B, Frederick, MD 21702 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases. 
 
Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.
Program Description
The AIDS and Cancer Virus Program (ACVP) is an integrated, multidisciplinary program that pursues basic and applied studies aimed at improving our understanding of AIDS-associated viruses, including studies intended to facilitate the improved diagnosis, prevention and treatment of HIV infection and AIDS, and AIDS related tumors, particularly those associated with other viruses such as KSHV. The Program consists of several independent but highly interactive research Sections headed by Principal Investigators, whose work spans from fundamental molecular virology through in vitro studies, to in vivo studies in non-human primate (NHP) models, to international viral epidemiology. The ACVP also has multiple Research Support Core Groups (Cores) that provide critical and often unique technical support capabilities to ACVP laboratories and other laboratories within the NCI and NIH, and to extramural investigators. 
 
Key Roles/Responsibilities
We are seeking a Research Associate II to join our dynamic, interactive, multidisciplinary research team studying the establishment, maintenance, and consequences of persistent HIV-1 infection and evaluating novel HIV-1 treatment and prevention approaches. The successful candidate will be able to work well in a small team environment, consistently follow detailed protocols and instructions, and keep careful records. Specific duties will include:
<ul>
<li>After an initial training period, work independently in a laboratory setting.</li>
<li>Mammalian cell culture, including culturing cells producing or infected with replication-competent SIV, HIV, or related viruses.</li>
<li>Handling blood- and tissue-derived nonhuman primate specimens from animals infected with SIV, SHIV, or stHIV.</li>
<li>Nucleic acid extractions and quantitative PCR-based analyses on nonhuman primate blood- and tissue-specimens.</li>
<li>Molecular cloning, site-directed mutagenesis, and other molecular biology techniques.</li>
<li>Flow cytometry assay specimen preparation and data acquisition.</li>
<li>Support detailed data analysis.</li>
<li>Maintain laboratory supplies and order as needed.</li>
<li>Maintain detailed laboratory notes and sample inventories.</li>
<li>Other duties as assigned.</li>
</ul>
Basic Qualifications

To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
<ul><li>
Possession of a Bachelor&rsquo;s degree from an accredited college or university according to the Council for Higher Education Accreditation (additional qualifying experience may be substituted for the required education); Foreign degrees must be evaluated for U.S. equivalency.</li><li>
In addition to the educational requirements, a minimum of five (5) years of relevant experience.</li><li>
Prior experience performing mammalian cell culture.</li><li>
Prior experience performing nucleic acid extractions, PCR-based techniques, and/or other molecular biology techniques.</li><li>
Ability to independently carry out experimental procedures and perform troubleshooting to ensure the timely completion of overall project goals.</li><li>
Competent with computer operations including Microsoft Outlook, Excel and PowerPoint.</li><li>
Must be able to obtain and maintain a security clearance.</li></ul>

Preferred Qualifications

Candidates with these desired skills will be given preferential consideration:
<ul><li>Prior experience staining samples and/or acquiring flow cytometry data.</li>
<li>Prior experience working with specimens containing infectious HIV/SIV or other infectious agents that are handled under Biosafety Level 2 biocontainment.</li>
<li>Prior experience working with specimens derived from nonhuman primates and/or humans.</li>
</ul>
Job Hazards
<ul>
<li>This position is subject to working with or have potential for exposure to 
animal(s) and/or animal material(s).</li>
<li>This position is subject to working with or have potential for exposure to 
infectious material, requiring medical clearance and immunizations.</li>
</ul>
Commitment to Diversity 
All qualified applicants will receive consideration for employment without regard to sex, race, color, ethnicity, age, national origin, citizenship, religion, physical or mental disability, medical condition, genetic information, pregnancy, family structure, marital status, ancestry, domestic partner status, sexual orientation, gender identity or expression, veteran or military status, or any other basis prohibited by law.
Compensation Range: 68,600.00 - 117,875.00
#readytowork</div>

Research Associate II - ACVP

<div>Natural Products Scientist II

Job ID: req4384 
Employee Type: exempt full-time 
Division: Applied &amp; Development Research Program 
Facility: Frederick: Ft Detrick 
Location: PO Box B, Frederick, MD 21702 USA

The Frederick National Laboratory is operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases. 
 
Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.
PROGRAM DESCRIPTION 
The Frederick National Laboratory for Cancer Research (FNLCR) is a Federally Funded Research and Development Center sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. With more than 2,000 employees, the FNLCR is responsible for pursuing its public health service mission via translational and applied biomedical research that is unique from academia, the pharmaceutical industry, or other federal contractors. There are excellent opportunities and support for collaborative research programs within the FNLCR and between the FNLCR and the NCI in developmental therapeutics, pharmacology, cancer genomics, computational biology, preclinical imaging, natural products, veterinary oncology, and solid and hematological malignancies and their preclinical models (including rare diseases and early passage patient-derived models). Outstanding core laboratories and an unparalleled environment for collaborations among basic, translational, and clinical scientists foster interdisciplinary research and translation of discoveries from the lab into the clinic. The selected candidate will join the Natural Products Support Group located at the NCI-Frederick campus.

The Natural Products Support Group provides scientific and technical support to the Developmental Therapeutics Program (DTP) of the NCI Division of Cancer Treatment and Diagnosis (DCTD), aiming to promote drug discovery from natural products, including those from the NCI Program for Natural Products Discovery (NPNPD). The group comprises several laboratories responsible for various natural product-based activities, including extracting plant, microbial, and marine biota; pre-fractionating and plating natural product extracts; isolating and identifying biologically active natural products; cryopreservation and microbial fermentations; and preparing drugs for in vitro and in vivo studies.

KEY ROLES/RESPONSIBILITIES
<ul>
<li>Isolation and structure elucidation of natural products identified in high-throughput screens.</li>
<li>Methods development towards the dereplication of the active principles from natural product fractions.</li>
<li>Managing a nuclear magnetic resonance (NMR) facility.</li>
<li>Generating reports and publications in the areas of isolation and structural elucidation of natural products from marine, microbial, and plant sources using state-of-the-art techniques.</li>
<li>Maintaining chemistry laboratory instrumentation, including liquid chromatography systems and mass spectrometers.</li>
</ul>
BASIC QUALIFICATIONS

To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
<ul><li>
Possession of a Doctoral degree in chemistry, pharmacology, or a related discipline from an accredited college or university according to the Council for Higher Education Accreditation (CHEA). Foreign degrees must be evaluated for U.S. equivalency.</li><li>
In addition to the education requirement, a minimum of two (2) years experience with an emphasis in the isolation and structural elucidation of natural products.</li><li>
Demonstrated proficiency in the use of NMR instrumentation and data interpretation.</li><li>
Experience in managing an NMR facility, including troubleshooting, maintenance, user training, and support.</li><li>
Demonstrated publication record in the field of natural products chemistry.</li><li>
Experience isolating active compounds from diverse natural product extract libraries derived from plants, marine invertebrates, and microbes.</li><li>
Using modern spectroscopic analytical techniques to isolate and characterize complex organic molecules from natural product extracts.</li><li>
Ability to work in a team environment.</li><li>
Ability to obtain and maintain a security clearance.</li></ul>

PREFERRED QUALIFICATIONS

Candidates with these desired skills will be given preferential consideration:
<ul><li>A minimum of five (5) years of post-graduate experience</li></ul> 

Commitment to Non-Discrimination 
All qualified applicants will receive consideration for employment without regard to sex, race, ethnicity, color, age, national origin, citizenship, religion, physical or mental disability, medical condition, genetic information, pregnancy, family structure, marital status, ancestry, domestic partner status, sexual orientation, gender identity or expression, veteran or military status, or any other basis prohibited by law. Leidos will also consider for employment qualified applicants with criminal histories consistent with relevant laws.

Pay and Benefits

Pay and benefits are fundamental to any career decision. That's why we craft compensation packages that reflect the importance of the work we do for our customers. Employment benefits include competitive compensation, Health and Wellness programs, Income Protection, Paid Leave and Retirement. More details are available here
103,100.00 - 172,625.00 USD
The posted pay range for this job is a general guideline and not a guarantee of compensation or salary. Additional factors considered in extending an offer include, but are not limited to, responsibilities of the job, education, experience, knowledge, skills, and abilities as well as internal equity, and alignment with market data.

The salary range posted is a full-time equivalent salary and will vary depending on scheduled hours for part time positions</div>

Natural Products Scientist II

<div>Digital Pathology Scientist, MDPL, CGR

Job ID: req4385 
Employee Type: exempt full-time 
Division: Clinical Research Program 
Facility: Rockville: 9615 MedCtrDr 
Location: 9615 Medical Center Drive, Rockville, MD 20850 USA

The Frederick National Laboratory is operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases. 
 
Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.
PROGRAM DESCRIPTION

The Cancer Genomics Research Laboratory (CGR) investigates the contribution of germline and somatic genetic variation to cancer susceptibility and outcomes in support of the NCI's Division of Cancer Epidemiology and Genetics (DCEG), the world's most comprehensive cancer epidemiology research group. CGR is located at the NCI-Shady Grove campus in Rockville, MD and operated by Leidos Biomedical Research, Inc. We care deeply about discovering the genetic and environmental determinants of cancer, and new approaches to cancer prevention, through our contributions to the molecular, genetic, and epidemiologic research of the 70+ principal investigators (PIs) in DCEG. Working in concert with epidemiologists, biostatisticians and basic research scientists in DCEG's intramural research program, CGR provides the capacity to conduct genome-wide discovery studies and targeted regional approaches to identify the heritable determinants of various forms of cancer. Within CGR, the Molecular and Digital Pathology Laboratory (MDPL) is dedicated to the support of genetic and epidemiologic studies for DCEG investigators through tissue profiling and image analysis. This includes the design and analysis of high throughput molecular epidemiologic studies using various types of &quot;omics&quot; technologies such as AI-based histomics, proteomics-based assays (immunohistochemistry, multiplex immunofluorescence), spatial transcriptomic assays and somatic genomic analyses. We are seeking a Digital Pathology Scientist to join our team and support large-scale, international epidemiological research on cancer etiology, progression, and outcomes through integrative analyses of risk factors and tissue profiling to inform prevention and clinical strategies. 
 
KEY ROLES/RESPONSIBILITIES

We are recruiting for a Digital Pathologist Scientist to be part of a group focused on large-scale image analysis in support of researchers within DCEG's Integrative Tumor Epidemiology Branch (ITEB). The position will involve working closely with an ITEB investigator and MDPL staff to define priorities, monitor study progress, manage project-specific imaging data, run image analysis, manage the resulting data, and conduct statistical analysis to support PI research. More specifically, key responsibilities for this position include:
<ul>
<li>Coordinate with existing laboratory, project management and analytical staff to track study progress from conception (developing analytical plans and study protocols) through completion (preparation of summary reports for presentation and publication).</li>
<li>Execute statistical analysis of epidemiologic and tissue-based data derived from image analysis of whole slide and tissue microarray (TMA) images of hematoxylin and eosin (H&amp;E), immunohistochemical (IHC), immunofluorescence (IF), and other state-of-the-art staining modalities including emerging spatial technologies.</li>
<li>Accurately maintain thorough documentation and version control of data management activities (data cleaning, harmonization, and statistical analysis)</li>
<li>Support process improvement and assay development activities in collaboration with CGR development resources and senior laboratory management staff.</li>
<li>Participate in the writing and review of laboratory SOPs to help ensure image quality and data is suitable for downstream analyses. Follow established protocols and assist with deviations and corrective actions.</li>
<li>Meet expected schedules and performance expectations in a fast-paced research environment.</li>
<li>Support a culture of continuous improvement and accountability; contribute to troubleshooting of issues associated with assay processing.</li>
<li>Support process improvement and assay development activities in collaboration with CGR development resources and senior management staff</li>
</ul>
BASIC QUALIFICATIONS

To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
<ul>
<li>Possession of a PhD degree from an accredited college or university according to the Council for Higher Education Accreditation (CHEA). Foreign degrees must be evaluated for U.S. equivalency.</li>
<li>In addition to the education requirement, a minimum of two (2) years related experience in the fields of histopathology, digital pathology and/or data science.</li>
<li>Strong analytical skills and experience with statistical software applications used in public health research, such as Stata and/or R, Python, C++ (please indicate relevant software applications and degree of proficiency).</li>
<li>Strong understanding of molecular biology.</li>
<li>Experience analyzing IHC/multiplex IHC, and/or ISH data.</li>
<li>Careful attention to detail.</li>
<li>Critical thinking skills and ability to identify, document and analyze important variables in an experiment.</li>
<li>Demonstrated ability to learn and adopt new concepts in biomarker analysis.</li>
<li>Collaborative, team-oriented approach to solving problems and achieving goals.</li>
<li>Strong organization skills, ability to multitask and manage time effectively.</li>
<li>Working knowledge of Windows-based computer operating systems and Microsoft Office suite.</li>
<li>Must be able to obtain and maintain a security clearance.</li>
</ul>
PREFERRED QUALIFICATIONS

Candidates with these desired skills will be given preferential consideration:
<ul>
<li>Advanced degree in epidemiology, molecular biology, data science, biostatistics, or a related field.</li>
<li>Familiarity with eLN and/or LIMS systems for sample and workflow tracking.</li>
<li>Knowledge of basic histological techniques including processing and embedding, microtomy/cryotomy, H&amp;E staining, slide coverslipping and how these variables relate to image and data quality.</li>
<li>Experience with digital slide scanners for brightfield and fluorescent applications.</li>
<li>Microscopic recognition of major human tissue types.</li>
<li>A general understanding of database organization and structure.</li>
<li>Experience with image analysis software such as Halo, QuPath, Visiopharm, Definiens, etc. (please indicate relevant software applications and level of proficiency).</li>
<li>Experience in the application of artificial intelligence (machine learning or deep learning) to pathology image analysis.</li></ul> 

Commitment to Non-Discrimination 
All qualified applicants will receive consideration for employment without regard to sex, race, ethnicity, color, age, national origin, citizenship, religion, physical or mental disability, medical condition, genetic information, pregnancy, family structure, marital status, ancestry, domestic partner status, sexual orientation, gender identity or expression, veteran or military status, or any other basis prohibited by law. Leidos will also consider for employment qualified applicants with criminal histories consistent with relevant laws.

Pay and Benefits

Pay and benefits are fundamental to any career decision. That's why we craft compensation packages that reflect the importance of the work we do for our customers. Employment benefits include competitive compensation, Health and Wellness programs, Income Protection, Paid Leave and Retirement. More details are available here
76,800.00 - 128,625.00 USD
The posted pay range for this job is a general guideline and not a guarantee of compensation or salary. Additional factors considered in extending an offer include, but are not limited to, responsibilities of the job, education, experience, knowledge, skills, and abilities as well as internal equity, and alignment with market data.

The salary range posted is a full-time equivalent salary and will vary depending on scheduled hours for part time positions</div>

Digital Pathology Scientist, MDPL, CGR

Join Frederick National Laboratory for Cancer Research and explore 4   exciting career opportunities. They're hiring for various roles with options for remote or on-site work. Apply today and become part of their innovative team.

Frederick National Laboratory for Cancer Research

ABOUT_COMPANY

Small Lab Animal Research Specialist

Research Associate II - ACVP

Natural Products Scientist II

Digital Pathology Scientist, MDPL, CGR