Qureos Mentor

Monte Rosa Therapeutics

<div>Overview:
<div>
Monte Rosa Therapeutics is searching for a Sr Research Associate - In Vivo to assist in executing pivotal proof-of-concept studies in pre-clinical models in mice of inflammation, immunology, and oncology, and assist in the cross-functional development of our research strategy. The role involves interacting with team members to design and execute <i>in vivo/ex vivo</i> pharmacology studies aimed at defining the activity and mechanism of action of compounds. This person will work primarily in our Animal Care Facility, ideally 10am-6pm, to oversee and perform afternoon/evening and weekend dosing of animals as part of study protocols. This role will have the opportunity to expand their skill set at the lab bench by performing a variety of <i>ex vivo/in vitro</i> experiments.
</div>Responsibilities:
<div>
Perform basic and intermediate veterinary technical tasks in mice independently, including the following:</div><p>
Administration of selected agents by PO, IP, SC routes.</p><div>
 Blood sampling techniques via multiple routes, including submandibular bleed.</div><div>
 Carry out tissue harvests at later time points based on study requirements.</div><div>
 Preparation of compound formulation for <i>in vivo</i> dosing.</div><div>
Optimize and perform studies to define target biology in mouse models of inflammation, oncology and immunity for <i>in vivo</i>, <i>in vitro</i> and <i>ex vivo </i>applications.</div><div>
Maintain accurate laboratory records/notebooks, procedures, and data summaries.</div><div>
Perform evening and weekend dosing of animals as part of study protocols.</div><div>
Conduct health checks to ensure animal welfare and identify any concerns.</div><div>
Carry out tissue harvests at later time points based on study requirements.</div><div>
Prepare and perform formulations for dosing studies.</div><div>
Oversee breeding programs, including monitoring litters and documenting outcomes.</div><div>
Assist with cage changes and husbandry tasks as needed.
</div><div>Processing time-sensitive biological samples.</div>
Qualifications:
<ul><li>BS/MS in Biology, Pharmacology, Animal Science, or related field with minimum 4 years relevant experience in an industry setting.</li><li>
AALAS certification at the ALAT level is preferred. LVT qualification is a plus.</li><li>
Ability to work flexible hours, including evenings and weekends as needed, is a must.</li><li>
Prior experience necessary in handling compounds for formulation preparation, with a strong emphasis on safety and proficiency in performing necessary calculations.</li><li>
Strong experience in animal handling is required, including compound administration by multiple routes, harvesting tissue and blood samples, and performing necropsy techniques. Experience with surgical techniques is a plus.
</li><li>Strong organizational skills and attention to detail.</li><li>
Experience in culturing mammalian cell lines is advantageous.</li><li>
Experience with pharmacodynamics assays of mouse tissue, including Western Blotting or JESS, ELISA/Mesoscale and flow cytometry is a plus, but not required.</li><li>
Willingness to learn new benchwork skills, including sample processing and cell culture.</li></ul></div>

Senior Research Associate I/II – In Vivo

<div>Overview:
<div>
Monte Rosa Therapeutics (MRT) is a clinical-stage biotechnology company pioneering the discovery and development of <i>molecular glue degraders (MGDs)</i> to eliminate disease-causing proteins previously considered undruggable. We are seeking an accomplished and collaborative Senior Director of Medicinal Chemistry to lead and shape our drug discovery efforts in Boston. This leadership role will be central to advancing our growing pipeline from hit identification through development candidate nomination and IND-enabling studies. The ideal candidate will bring deep medicinal chemistry expertise, strong leadership capabilities, and a passion for driving innovative science toward transformative medicines.</div>
Responsibilities:
<ul><li>Lead Monte Rosa&rsquo;s Boston Medicinal Chemistry group with scientific rigor, creativity and urgency, to deliver novel protein degraders into clinical development.</li><li>
Design and execute medicinal chemistry strategies from early discovery through candidate selection, applying structure- and property-based design.</li><li>
Drive compound design and optimization, integrating SAR, ADME/DMPK, pharmacology, and safety data to achieve optimal target product profiles.</li><li>
Collaborate with computational chemistry to apply machine learning and AI tools for molecular design and optimization.</li><li>
Work as a team and in close partnership with Basel Medicinal Chemistry and global Discovery Chemistry groups.</li><li>
Inspire and develop a team of experienced medicinal chemists, fostering innovation, collaboration, and cross-site synergy.</li><li>
Partner cross-functionally with biology, biophysics, DMPK, and computational teams to enable data-driven decisions and accelerate discovery timelines.</li><li>
Direct and manage external CRO partnerships, ensuring efficient execution of complex synthetic routes and timely compound delivery.</li><li>
Represent Monte Rosa&rsquo;s science and strategy at internal governance meetings and external scientific forums, with clarity and impact.</li><li>
Mentor and develop next-generation scientific leaders within the medicinal chemistry organization.</li><li>
</li></ul>
Qualifications:<br>
<div></div><ul><li>
PhD in Organic or Medicinal Chemistry with 15+ years of post-graduate experience in small molecule drug discovery within biotech or pharma.</li><li>
Proven track record of leadership in advancing programs from hit-to-lead through candidate nomination and IND-enabling studies.</li><li>
Knowledge and ideally experience proximity inducing modalities</li><li>
Demonstrated excellence in modern medicinal chemistry, including property-based optimization, hypothesis-driven design, and integration of structure-based and computational approaches.</li><li>
Deep understanding of DMPK, pharmacology, and safety optimization principles.</li><li>
Strong synthetic chemistry foundation with creativity in solving complex chemical challenges.</li><li>
Experience of managing cross-functional and cross-site teams, including external research collaborations and CRO networks.</li><li>
Exceptional communication and influencing skills, capable of articulating scientific vision and strategy across levels and disciplines.</li><li>
Track record of building strong teams</li><li>
Strategic thinker with the ability to balance hands-on problem solving and high-level scientific direction.</li></ul></div>

Senior Director, Medicinal Chemistry

<div>Overview:<p></p><div><br>
Monte Rosa Therapeutics is seeking a Research Associate/Senior Research Associate - Biology to support early target validation in immunology and inflammation, aiding in the advancement of our molecular glue degraders into clinic. The successful candidate will collaborate with team members to design and execute <i>in vitro</i> experiments focused on determining the activity and mechanism of action of compounds. This role requires hands-on laboratory work, conducting a variety of <i>in vitro</i> experiments.
</div>Responsibilities:<div><br>
<ul><li>Assist in the planning and implementation of diverse experimental protocols aimed at evaluating the efficacy and mechanism of action of Molecule Glue Degraders.</li><li>Develop, optimize, and execute in vitro functional assays using primary immune cells to assess cellular responses, cytokine production, and other immunological parameters.</li><li>Support downstream analytical techniques including, but not limited to, flow cytometry, cytokine assays (such as ELISA, MSD, etc) and Western blotting to validate experimental outcomes.</li><li>Perform routine and specialized cell culture procedures using primary cells or cell lines to support in vitro studies. Such work includes isolating specific cell populations from primary cells, cell maintenance, and potential differentiation and stimulation assays.
</li><li>Collaborate with in vivo teams to receive and process biological samples for downstream ex vivo analysis. No live animal work is involved
</li><li>Maintain accurate and detailed laboratory records of experimental design, protocols, raw data, and analyzed results in accordance with internal documentation standards.</li><li>Work closely with cross-functional teams, including senior scientists and project managers, to ensure alignment of experimental strategies with project goals.</li></ul></div>
Qualifications:<div><br>
<ul><li>Bachelor&rsquo;s or Master&rsquo;s degree in Immunology, Molecular Biology, Cell Biology, or a closely related scientific discipline.</li><li>Minimum of 2 year of relevant hands-on experience in an industrial or biotechnology research setting.</li><li>Proficiency in primary cell isolation and culture techniques.</li><li>Familiarity with standard molecular and cell biology techniques, including flow cytometry, ELISA, MSD, and Western blot.</li><li>Experience with ex vivo assays or whole blood assays preferred.</li><li>Strong attention to detail, with excellent documentation and record-keeping skills.</li><li>Strong communicator and team player equipped with natural curiosity</li></ul></div></div>

Research Associate II – Immunology

Join Monte Rosa Therapeutics and explore 3   exciting career opportunities. They're hiring for various roles with options for remote or on-site work. Apply today and become part of their innovative team.

Monte Rosa Therapeutics

ABOUT_COMPANY

Senior Research Associate I/II – In Vivo

Senior Director, Medicinal Chemistry

Research Associate II – Immunology