Qureos Mentor

NextGen Tides

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 Job Title: Scientist / Senior Scientist &ndash; Oligonucleotide Chemistry
 
 
 
 
 
 Location: [San Diego,CA]
 
 
 Type: Full-time
 
 
 About NextGen Tides
 
 
 NextGen Tides is a fast-growing biotech startup focused on oligonucleotide and conjugation technologies. We are building next-generation capabilities in ASO, siRNA, PMO, peptide conjugation, and AOC technologies to drive the future of therapeutics.
 
 
 
 
 
 We are looking for a
 
 Scientist or Senior Scientist
 
 to join our core chemistry team. This is a rare opportunity to join early, help build the foundation of our platform, and make a tangible impact on our scientific direction.
 
 
 
 
 
 The Role
 
 
 If you are passionate about oligonucleotide synthesis, modified chemistries, and advanced analytical workflows, we want to hear from you. You will be hands-on in the lab, executing high-quality synthesis and purification while optimizing methods for both client projects and internal R&amp;D.
 
 
 
 
 
 
 What You&rsquo;ll Do
 
 
 <ul>
 <li>
 
 Oligo Synthesis:
 
 Write protocols and perform solid-phase synthesis of DNA, RNA, ASO, siRNA, PMO, and modified oligos.
 </li>
 <li>
 
 Analysis &amp; QC:
 
 Operate and interpret data using
 
 LC&ndash;MS (Waters)
 
 and
 
 HPLC (Agilent)
 
 to ensure purity and identity.
 </li>
 <li>
 
 Instrument Management:
 
 Maintain and troubleshoot automated oligo synthesizers (
 
 Mermade / Dr. Oligo
 
 ).
 </li>
 <li>
 
 Purification:
 
 Execute purification and deprotection workflows with a focus on high quality and yield.
 </li>
 <li>
 
 Innovation:
 
 Support peptide&ndash;oligo conjugates and AOC-related chemistries, contributing to overall platform development.
 </li>
 <li>
 
 Optimization:
 
 Develop and refine synthesis and purification methods to improve efficiency for internal programs.
 </li>
 <li>
 
 Lab Operations:
 
 Maintain lab excellence, including instrument upkeep, documentation, and QC standards.
 </li>
 </ul>
 
 
 
 
 
 What You Bring
 
 
 <ul>
 <li>
 
 Education:
 
 PhD in Chemistry, Chemical Biology, or a related field (0&ndash;5+ years experience)
 
 OR
 
 MS/BS with strong, hands-on industry experience.
 </li>
 <li>
 
 Technical Expertise:
 
 Deep experience with oligonucleotide solid-phase synthesis and automated synthesizers.
 </li>
 <li>
 
 Analytical Skills:
 
 Strong proficiency in LC&ndash;MS, HPLC, and oligo purification workflows.
 </li>
 <li>
 
 Chemistry Knowledge:
 
 Familiarity with modified backbones (PS, PO) and nucleoside chemistry.
 </li>
 <li>
 
 Soft Skills:
 
 A "startup mindset"&mdash;you are independent, organized, a clear communicator, and a proactive problem solver.
 </li>
 </ul>
 
 
 Preferred Qualifications (Nice to Have)
 
 
 <ul>
 <li>
 Experience with
 
 conjugation chemistries
 
 (peptides, lipids, ligands).
 </li>
 <li>
 Experience building protocols from scratch in a startup environment.
 </li>
 </ul>
 
 
 Why Join NextGen Tides?
 
 
 <ul>
 <li>
 
 Impact:
 
 Build the foundation of a new biotech platform and see the direct result of your work.
 </li>
 <li>
 
 Equity:
 
 Ownership in the company you are helping to build.
 </li>
 <li>
 
 Compensation:
 
 Competitive base salary + potential year-end bonus.
 </li>
 <li>
 
 Benefits:
 
 Healthcare insurance and Paid Time Off (PTO).
 </li>
 <li>
 
 Culture:
 
 A collaborative, fast-paced environment where technical innovation is rewarded.
 </li>
 </ul>
 
 How to Apply
 
 
 Ready to build the next generation of oligonucleotide therapeutics? Click Apply Now or send your resume to info@nextgentides.com
 
 
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Synthesis Scientist

Join NextGen Tides and explore 1   exciting career opportunities. They're hiring for various roles with options for remote or on-site work. Apply today and become part of their innovative team.

NextGen Tides

ABOUT_COMPANY

Synthesis Scientist