Qureos Mentor

TWIST BIOSCIENCE

<div><h2 class="jobSectionHeader"><b>Scientist / Sr Scientist / Staff Scientist (DNA Synthesis Chemistry) in </b><b>South San Francisco, CA</b></h2>
<h3 class="jobSectionHeader"><b>Job Description</b></h3>
<p>
The R&amp;D team at Twist Bioscience is searching for a curious, thoughtful, and driven Scientist to help us push the limits of our silicon-based DNA synthesis platform. We are looking for a true interdisciplinary scientist, someone who lives at the intersection of <b>Nucleic Acid Chemistry</b>, <b>Surface Science</b>, and <b>Data Analysis</b>.</p>
<p>
You will focus on the fundamental chemistry that powers our platform. You must be able to recite the phosphoramidite cycle in your sleep, but you also need the coding skills to analyze the resulting NGS data and the biological intuition to understand how those molecules perform in downstream applications. We are looking for people who have:</p>
<ul>
<li><b>Deep technical knowledge.</b> You understand the mechanism of DNA synthesis, side reactions, and how modified bases interact with the silicon surface.</li>
<li><b>Fire in the belly.</b> You are obsessed with optimization. You want to reduce error rates and increase yield.</li>
<li><b>Data fluency.</b> You don't rely on Excel. You write your own scripts to visualize complex datasets and identify root causes.</li>
</ul>
<p><b>Job title and compensation will be determined based on several factors, including but not limited to the candidate's years of experience, individual skills, knowledge, and abilities.</b></p>
<h3 class="jobSectionHeader"><b>
Key Responsibilities:</b></h3>
<ul><li>Lead research projects to optimize the DNA synthesis cycle (coupling, oxidation, deblocking) on our proprietary silicon platform.</li>
<li>Design and execute experiments using modified nucleic acid chemistries to solve stability and fidelity challenges (e.g., mitigating depurination or improving coupling efficiency).</li>
<li>Investigate surface chemistry parameters and their impact on synthesis quality; bridge the gap between material science and organic chemistry.</li>
<li>Code your own analysis: Use Python or R to ingest NGS datasets, visualize error profiles, and determine if chemical changes improved the sequence.</li>
<li>Collaborate with biologists to validate your chemical improvements using gene assembly and library prep workflows.</li>
<li>Document and communicate results clearly and succinctly.</li>
</ul><h3 class="jobSectionHeader"><b>Qualifications:</b></h3>
<ul><li>Experience in Chemistry, Chemical Biology or combination of closely-related field and experience.
<ul><li><b>Scientist</b><br>
Requires a PhD and 0-2 years of previous professional experience;<br>
or a master's degree and 3-5 years of work experience</li>
<li><b>Sr Scientist</b><br>
Requires a Ph.D. and 2-5 years of professional experience (postdoc may count);<br>
or a master's degree and 5-7 years of work experience</li>
<li><b>Staff Scientist</b><br>
Requires a Ph.D. and 5-8 years of professional experience (postdoc may count);<br>
or a master's degree and 7 years of work experience</li>
</ul></li><li>Mastery of DNA Synthesis: Deep understanding of phosphoramidite chemistry and solid-phase synthesis cycles.</li>
<li>Modified Chemistry Expertise: Familiarity with non-standard chemistries, including stability modifications, backbone alterations, and linkers for downstream functionalization.</li>
<li>Enzymatic Versatility: Comprehensive knowledge of the full nucleic acid toolkit (ligases, exonucleases, kinases, polymerases) and how to apply them to manipulate DNA structure for any application.</li>
<li>NGS Workflow Knowledge<b>:</b> Understanding of library preparation and next-generation sequencing fundamentals to ensure synthesis products are compatible with downstream analysis.</li>
<li>Coded Data Analysis: Proven ability to use Python, R, or JMP to analyze and visualize large datasets (NGS data preferred).</li>
<li>Surface Chemistry: Experience with surface functionalization or DNA-surface interactions is a major plus.</li>
</ul><h3 class="jobSectionHeader"><b>About Twist Bioscience</b></h3>
<p>
Twist Bioscience synthesizes genes from scratch, known as &quot;writing&quot; DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.</p>
<p>
At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.</p>
<p>
Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.</p></div>

Scientist / Sr Scientist / Staff Scientist (DNA Synthesis Chemistry) in South San Francisco, CA

<div><h2 class="jobSectionHeader"><b>Scientist/ Sr Scientist / Staff Scientist (</b><b>DNA Synthesis Process Development) </b><b>i</b><b>n South San Francisco, CA</b></h2>
<h3 class="jobSectionHeader"><b>Job Description</b></h3>
<p>
The R&amp;D team at Twist Bioscience is searching for a curious, thoughtful, and driven Scientist with excellent lab hands to help us innovate on our core technology. We are looking for a <b>&quot;Triple Threat&quot; Scientist</b>: someone with strong Molecular Biology skills, a solid grasp of DNA Chemistry, and the ability to code their own data analysis.</p>
<p>
Your mission is to close the loop. You will take the DNA from the chip, perform complex enzymology and library preparation, and analyze the sequencing data to prove that our synthesis innovations are working. We are looking for people who have:</p>
<ul>
<li><b>Excellent Lab Hands.</b> You can handle complex gene assemblies, low-input library preps, and difficult PCRs with precision.</li>
<li><b>A Chemist's Brain.</b> You aren't just a user; you understand the underlying chemical cycle that created the DNA.</li>
<li><b>Data fluency.</b> You can look at a raw sequencing dataset and tell a story with data.</li>
</ul>
<p><b>Job title and compensation will be determined based on several factors, including but not limited to the candidate's years of experience, individual skills, knowledge, and abilities.</b></p>
<h3 class="jobSectionHeader"><b>
Key Responsibilities:</b></h3>
<ul><li>Design and execute downstream validation workflows for new synthesis chemistries.</li>
<li>Perform complex nucleic acid enzymology: Utilizes the full range of enzymatic tools (polymerases, ligases, nucleases, kinases) to repair, modify, and assemble DNA from chip to library.</li>
<li>Execute NGS Library Prep: Select and run the appropriate library prep workflows (Illumina/Nanopore) to reveal specific synthesis error modes.</li>
<li>Code your own analysis: Use Python or R to analyze NGS data, generate figures, and correlate biological performance with upstream synthesis conditions.</li>
<li>Troubleshoot synthesis issues by understanding the phosphoramidite cycle and identifying chemical shortcomings.</li>
<li>Move projects forward efficiently and prioritize tasks in accordance with the company's goals.</li>
</ul><h3 class="jobSectionHeader"><b>Qualifications:</b></h3>
<ul><li>Experience in Molecular Biology, Genomics, Biochemistry, or combination of closely-related field and experience.
<ul><li><b>Scientist</b><br>
Requires a PhD and 0-2 years of previous professional experience;<br>
or a master's degree and 3-5 years of work experience</li>
<li><b>Sr Scientist</b><br>
Requires a Ph.D. and 2-5 years of professional experience (postdoc may count);<br>
or a master's degree and 5-7 years of work experience</li>
<li><b>Staff Scientist</b><br>
Requires a Ph.D. and 5-8 years of professional experience (postdoc may count);<br>
or a master's degree and 7 years of work experience</li>
</ul></li><li>Expert Enzymology: You know anything an enzyme can do on a nucleic acid. Deep hands-on experience with complex manipulations, gene construction, and repair workflows.</li>
<li>Handling Modified Templates: Experience amplifying or manipulating nucleic acids with non-standard modifications (e.g., stability mods, backbone changes, or novel linkers).</li>
<li>DNA Chemistry Literacy: Must understand the fundamentals of the DNA synthesis cycle (coupling, deblocking, oxidation) and how errors arise.</li>
<li>Coded Data Analysis: Proven ability to use Python or R to analyze experimental results (sequencing alignment, error rate calculation, plotting).</li>
<li>Comfortable working in a fast-paced R&amp;D environment.</li>
</ul><h3 class="jobSectionHeader"><b>About Twist Bioscience</b></h3>
<p>
Twist Bioscience synthesizes genes from scratch, known as &quot;writing&quot; DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.</p>
<p>
At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.</p>
<p>
Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.</p></div>

Scientist/ Sr Scientist / Staff Scientist (DNA Synthesis Process Developme

<div><h2 class="jobSectionHeader"><b>Scientist / Sr Scientist / Staff Scientist - DNA Synthesis (in SSF, CA)</b></h2>
<h3 class="jobSectionHeader"><b>Job Description</b></h3>
<p>
The R&amp;D team at Twist is searching for a curious, thoughtful, and driven molecular biologist with excellent lab hands to help us develop new products and applications in the Synthetic Biology (SynBio) space. You will use molecular biology to improve existing methods for gene synthesis as well as create entirely new ones. Leveraging our silicon-based, massively-parallel DNA synthesis platform, you will perform experiments for synthesis, assembly, cloning, scale-up, sequencing, and characterization of DNA. We are looking for people who have:</p>
<ul>
<li>Deep technical knowledge. You know exactly what's going on in the tube</li>
<li>Fire in the belly. You want to move fast and see your work turn into real products that people use. The Pareto principle is in your blood.</li>
<li>Common sense. Your scientific intuition is usually correct. Occam's razor is your friend.</li>
<li>Your work will be mainly at the bench; however, you will have the opportunity to use high-throughput robotic instruments and coding and bioinformatics tools to expand your expertise. You will work alongside and learn from some of the best scientists and bioinformaticians in the business.</li>
</ul>
<p><b>Job title and compensation will be determined based on several factors, including but not limited to the candidate's years of experience, individual skills, knowledge, and abilities.</b></p>
<h3 class="jobSectionHeader"><b>
Key Responsibilities:</b></h3>
<ul><li>Lead molecular biology research projects in DNA synthesis, assembly, cloning, scale up, sequencing, and characterization.</li>
<li>Independently design and execute experiments and analyze experimental data.</li>
<li>Move projects forward efficiently / manage time and resources effectively / prioritize tasks in accordance with the company's goals.</li>
<li>Document and communicate results clearly and succinctly</li>
<li>Discuss experimental results with other team members and stakeholders</li>
<li>Work collaboratively with a diverse group of scientists and bioinformaticians</li>
<li>Coordinate with internal Twist teams, including product management, manufacturing, and QC/QA, on cross-functional projects</li>
<li>Solicit technical input from others/participate in scientific discussions / come up with new ideas</li>
<li>Be helpful/collaborative / proactive</li>
<li>Stay up to date with new developments, companies, and technologies</li>
<li>Be the ultimate subject matter expert, and understand all aspects of your work as profoundly as possible, including details that are adjacent (as opposed to directly related) to your project/experiment.</li>
</ul><h3 class="jobSectionHeader"><b>What You'll Bring to the Team</b><b>:</b></h3>
<ul><li>Deep technical knowledge in molecular biology methods, with a focus on nucleic acids. Extensive experience in DNA synthesis, assembly, and manipulation methods is a must</li>
<li>Broad experience with DNA cloning and the different methods for DNA amplification using cells or enzymes</li>
<li>A track record of successful and creative method development</li>
<li>Broad experience in bacterial cell culture and plasmid biology</li>
<li>Strong background in NGS library preparation methods, sequencing technologies, and data analysis</li>
<li>Proficient in bioinformatics and bioinformatics tools, including genome alignment, mapping, variant calling, and annotation, with the ability to conduct analyses and effectively communicate requirements to bioinformaticians.</li>
<li>Excellent communication and interpersonal skills and a demonstrated ability to collaborate effectively within a team.</li>
<li>Independent, driven, and creative</li>
</ul> <h3 class="jobSectionHeader"><b>Qualifications:</b></h3>
<ul><li>Experience in Molecular Biology, Genomics, Biochemistry, or combination of closely-related fields and experience.</li>
<li><ul><li><b>Scientist</b><br>
Requires a PhD and 0-2 years of previous professional experience;<br>
or a master's degree and 3-5 years of work experience</li>
<li><b>Sr Scientist</b><br>
Requires a Ph.D. and 2-5 years of professional experience (postdoc may count);<br>
or a master's degree and 5-7 years of work experience</li>
<li><b>Staff Scientist</b><br>
Requires a Ph.D. and 5-8 years of professional experience (postdoc may count);<br>
or a master's degree and 7 years of work experience</li>
</ul></li><li>Extensive experience in molecular biology of nucleic acids</li>
<li>Familiarity with Python, R, or equivalent programming languages</li>
<li>Experience with liquid-handling systems and automation is a plus</li>
</ul><h3 class="jobSectionHeader"><b>About Twist Bioscience</b></h3>
<p>
Twist Bioscience synthesizes genes from scratch, known as &quot;writing&quot; DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.</p>
<p>
At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.</p>
<p>
Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.</p></div>

Scientist / Sr Scientist / Staff Scientist - DNA Synthesis (in SSF, CA)

Join TWIST BIOSCIENCE and explore 3   exciting career opportunities. They're hiring for various roles with options for remote or on-site work. Apply today and become part of their innovative team.

TWIST BIOSCIENCE

ABOUT_COMPANY

Scientist / Sr Scientist / Staff Scientist (DNA Synthesis Chemistry) in South San Francisco, CA

Scientist/ Sr Scientist / Staff Scientist (DNA Synthesis Process Developme

Scientist / Sr Scientist / Staff Scientist - DNA Synthesis (in SSF, CA)