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Associate Director, Translational Medicine

Waltham, United States

Who We Are:

Cogent Biosciences is a publicly traded biotechnology company dedicated to developing precision therapies for genetically defined diseases. By leveraging validated biology and a rational drug discovery approach, Cogent aims to create real solutions that address the underlying drivers of disease and offer meaningful hope to patient's.

The company's lead therapeutic candidate, bezuclastinib, is a highly selective tyrosine kinase inhibitor designed to potently target KIT D816V and other mutations in KIT exon 17. These mutations are known drivers of systemic mastocytosis (SM) and advanced gastrointestinal stromal tumors (GIST) - both serious conditions driven by oncogenic KIT signaling. Bezuclastinib is currently being evaluated in multiple registration-directed trials across Non-Advanced SM (NonAdvSM), Advanced SM (AdvSM), and GIST. In July 2025, Cogent announced that its registration-direct SUMMIT trial in patients with NonAdvSM achieved statistical significance across all primary and key secondary endpoints, and the company is on track to file its first New Drug Application for this patient population by the end of 2025. The company also remains on track to announce top-line results for its APEX trial in patients with AdvSM in the second half of 2025 and for its PEAK trial in patients with GIST by the end of 2025. The company also has an ongoing Phase 1 study of its novel internally discovered FGFR2 inhibitor, and the Cogent Research Team is developing a portfolio of novel targeted therapies to help patients fighting other serious, genetically driven diseases targeting mutations in ErbB2, PI3Kα and KRAS.

Through its commitment to precision medicine and targeted innovation, Cogent Biosciences is working to transform the treatment landscape for patients with serious and underserved diseases. By leveraging validated biology and a rational drug discovery approach, Cogent aims to create real solutions that address the underlying drivers of disease. Our culture of inquisitiveness fuels continuous learning and innovation; we challenge assumptions, ask bold questions, and embrace a mindset of discovery to uncover transformative insights.

The Role:

The Associate Director, Translational Medicine plays a critical role in both Clinical Development and in support of nonclinical Research at Cogent. Reporting to Senior Director, Translational Medicine, you will play a critical role in representing the Translational Medicine function and provide subject matter expertise on cross-functional project teams

In partnership with Discovery Research and Clinical Development teams, you will lead the implementation of biomarker strategies to accelerate program transition from discovery research to clinical development. You will support decision making on patient selection/stratification, and utilizing biomarkers to predict drug efficacy and/or assess biological activity in humans and lead scientific and technical management implementation of clinical trial biomarker strategy.

Responsibilities:

Contribute to design of biomarker and/or diagnostic strategies for clinical programs
Identify and utilize appropriate biomarkers to predict drug efficacy and/or assess biological activity in humans
Oversee the use of biomarkers in clinical studies, writing protocols for incorporation of biomarkers in clinical trials, training trial sites or clinical CROs to ensure protocols are followed, and contribution to regulatory documents
Analyze, interpret and report results of clinical biomarker analyses, including support of regulatory filings, congress presentations and publications.
Direct the development, outsourcing and validation of clinically applicable biomarker assays
Function as key point of contact with biomarker vendors
In partnership with Research team, contribute to the identification of biomarkers, generation, and analysis of biomarker data to support assessment of target engagement, pathway modulation and disease modification to understand mechanism of action
Collaborate with Research team for successful translation of nonclinical research to biomarkers suitable for implementation in clinical studies

Qualifications:

PhD in Biology, Pharmacology, Genetics/Genomics, or other related discipline with 5+ years of relevant biopharmaceutical industry experience.
Strong understanding of clinical development and experience in clinical biomarker study execution including vendor management, data flow, interpretation and reporting. Experience with oncology trials is a plus.
Current knowledge of FDA, EMA, ICH, GCP/GLP and other applicable guidelines related to qualification and validation of bioanalytical and biomarker assays
Experience in broad range of platform technologies for biomarker assays (e.g., IHC, NGS, flow cytometry, PCR, and other technologies used in tumor tissue and liquid biopsies)
Proficiency in data analysis software such as Spotfire or R
Excellent interpersonal, leadership, communication, and time-management skills
Desire to work within a fast-paced, innovative, and collaborative environment

Salary Range:

$175,000 - 220,000 USD

Target Bonus: 20%

Exact compensation will vary based on skills, experience, and location.

Our Locations

Waltham, MA: Our Boston office includes an open office layout that has recently undergone a makeover designed for collaboration and giving our employees the best work place possible. Free access is provided for both on-site parking and gym facilities in the building.

Boulder, CO: We have just moved into our new state-of-the art Research Facility in the fast-growing biopharmaceutical hub in the greater Denver/Boulder corridor. Our CEO is based full-time in this location and we are proud to call this the home of Cogent's discovery research organization.

Our Offer To You

To attract the very best talent, we offer a generous benefits package that includes competitive pay, performance-based bonus, stock options, insurance coverage (health, dental, life, and disability), competitive time-off, a 401(k) plan, and commuter/parking benefits.

We are proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce. We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability, or any other status protected under federal, state, or local law. All employment is decided on the basis of qualifications, merit, and business need.

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