Associate Scientist

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. This is an exciting time to join Crinetics as we shape our organization into the world’s premier fully integrated endocrine company from discovery to patients. Join our team as we transform the lives of others.

Position Summary:

The Associate Scientist, In Vivo Pharmacology will work collaboratively and be responsible for performing a variety of pre-clinical in vivo experiments. The work will support projects at various stages of development thereby allowing the selected candidate to play an active role in our drug discovery and development efforts to advance small molecule therapeutics for endocrine disorders and endocrine-related cancers.

Essential Job Functions and Responsibilities:

These may include but are not limited to:

• Design and conduct pre-clinical in vivo experiments to evaluate the pharmacodynamics, pharmacokinetics, and safety of therapeutic candidate molecules.
• Develop new animal models for evaluating novel small molecules for endocrine diseases
• Demonstrate a high level of initiative to troubleshoot and accurately perform in vivo studies.
• Ensure that the care and welfare of laboratory animals is in accordance with regulations and IACUC protocols.
• Generate and manage purchase orders, contracts, and other related documents.
• Present findings at team and departmental meetings.
• Perform animal husbandry to conduct biological assays.
• Run and troubleshoot biomarker assays e.g. ELISAs, LUMINEX assays.
• Analysis of experimental data using MS Office, PRISM or comparable software
• Comply with company established practices and procedures, including laboratory notebooks, computer files, quality and regulatory guidelines, and safety standards.
• Other duties as assigned

Education and Experience:

• Bachelor’s in Biology, Pharmacology, Neuroscience, Toxicology or related discipline with a minimum of 8 years of significant and relevant experience or alternatively Master’s degree with a minimum of 6 years of significant and relevant experience.
• Proven hands-on proficiency in rodent (rats and mice) handling procedures and in vivo skills including dosing (IV, PO, SC) blood and tissue collection, necropsy, etc. Experience in designing and conducting rodent in vivo pharmacology studies
• Experience with ELISA and biomarker assays
• Proficient in basic surgical techniques in rodents.
• Must be independent and able to follow pre-established experimental designs, as well as develop new methods and protocols or technologies as needed.
• Strong communication skills and ability to effectively communicate and present summaries of research results to team members
• Strong organizational skills with great attention to details and ability to troubleshoot problems.
• Strong work ethic, ability to multi-task and be enthusiastic for animal and laboratory work.

Physical Demands and Work Environment:

Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities.

Laboratory Activities (if applicable): Biology, chemical laboratory and vivarium environments experience needed. Environmental health and safety requirements also apply.

Travel:

You may be required to travel for up to 5% of your time.

Equal Opportunity Employer:

Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws

Salary Range

The salary range for this position is: $107,000 - $134,000.

In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.