Click Chemist – Therapeutics & Digital Twin Integration

Job Description: Click Chemist – Therapeutics & Digital Twin Integration

Location: Dubai (preferred) / Hybrid for exceptional candidates

Compensation: Competitive salary + equity options + performance-based incentives

Start Date: Immediate — we’re scaling fast

About Us

Prepaire Labs is building the operating system of biology — a first-of-its-kind, open-architecture platform integrating AI-driven drug discovery, precision diagnostics, and real-time Digital Twins.

Our ecosystem includes:

• Clicktromics™: AI + Click Chemistry for targeted therapeutics.
• GenetiQ: Patient-specific Digital Twins for precision health.
• Prepaire SDK & Marketplace: A plug-and-play developer platform for clinics, biotech, and researchers.

We are uniting graph neural networks, diffusion models, federated learning, and click chemistry-driven pipelines to accelerate therapeutic design and validation at scale.

Position Overview

We are seeking a Click Chemist with expertise in bioorthogonal chemistry and drug conjugation strategies to lead the development of our therapeutic pipeline. The ideal candidate will bridge wet-lab chemistry with our AI-driven digital twin simulations, enabling rapid, modular, and precise therapeutic design.

This role requires a hands-on experimentalist and strategic thinker who can design, optimize, and validate click chemistry reactions in biological systems, while collaborating with computational and data science teams.

Key Responsibilities

• Therapeutic Design
• Develop and optimize bioorthogonal click reactions (e.g., azide-alkyne cycloaddition, tetrazine ligation, SPAAC, etc.) for targeted drug conjugates and delivery systems.
• Apply click chemistry to bioconjugation, antibody-drug conjugates (ADCs), nanoparticle surface modifications, and biomolecule labeling.
• Work closely with AI/data teams to translate reaction kinetics and efficiency data into simulation models for digital twin validation.
• Research & Development
• Design and execute synthetic pathways for functionalized small molecules, polymers, and biomolecules using click chemistry methods.
• Evaluate reaction scalability, reproducibility, and integration into preclinical pipelines.
• Support the development of click chemistry-enabled diagnostics for precision health.
• Collaboration & Integration
• Partner with computational chemists, structural biologists, and AI scientists to feed real-world chemistry data into Prepaire’s AI/ML-driven design loops.
• Interface with the Dubai lab team to establish SOPs, workflows, and throughput pipelines.
• Contribute to IP generation and patent strategy in the field of click chemistry-based therapeutics.

Qualifications

Education & Training

• PhD in Organic Chemistry, Chemical Biology, Medicinal Chemistry, or related discipline.
• Postdoctoral or industry experience in bioorthogonal / click chemistry highly preferred.

Experience

• 3–7+ years of direct experience in click chemistry applications (academic or industry).
• Proven track record in developing bioorthogonal conjugation methods for biomolecules.
• Experience in therapeutic or diagnostic applications (ADCs, imaging agents, nanomedicine).
• Strong publication record or patents in the field of click chemistry.

Technical Skills

• Mastery of CuAAC, SPAAC, IEDDA, SuFEx, and related click reactions.
• Analytical expertise in NMR, LC-MS, HPLC, fluorescence labeling, bioconjugation assays.
• Familiarity with protein chemistry, polymer chemistry, or nanomaterial functionalization.
• Understanding of drug delivery systems, pharmacokinetics, and biomolecular targeting.

Soft Skills

• Innovative thinker with a translational mindset — from bench to clinical application.
• Strong communication skills, able to collaborate across chemistry, biology, and AI disciplines.
• Entrepreneurial drive to contribute to a fast-paced startup environment.

What We Offer

• Competitive salary aligned with international biotech standards.
• Equity participation in a high-growth health-tech venture.
• Opportunity to pioneer first-in-class therapeutics at the interface of chemistry, AI, and medicine.
• Access to state-of-the-art labs in Dubai and Boston, with global collaboration opportunities.
• Direct impact on the development of the world’s first integrated digital twin + chemistry platform.

How to Apply

If you are passionate about supporting a high-performing team in an exciting, fast-paced industry, we’d love to hear from you! Please submit your CV along with a cover letter detailing your relevant experience and why you believe you’d be a great fit for Prepaire to jobs@prepaire.com

Job Type: Full-time

Pay: AED20,000.00 - AED40,000.00 per month