Scientist, Discovery Immunology

This is a full-time, on-site position in Lebanon, NH.

Lifordi Immunotherapeutics, Inc. is a clinical-stage biotechnology company leveraging the success of antibody-drug conjugates (ADCs) for the treatment of autoimmune and inflammatory disorders.  

We are seeking a self-motivated and experienced Scientist to join our research team located in Lebanon, New Hampshire to pioneer the next generation of antibody-targeted siRNA/ASO therapeutics for chronic inflammatory and autoimmune diseases. This is an opportunity to do meaningful work in a fast-paced start-up environment where scientific contributions are highly visible, valued, and impact the company’s strategic direction. The ideal candidate has earned a Ph.D. in immunology, biochemistry or an equivalent scientific discipline. Experience with in vivo studies including handling, tissue collection, and cell isolation is essential. Proficiency expected with immunological cell-based assays including Th1/Th2 and M1/M2 assays. Experience with primary cell assays (including blood) is a plus. The successful candidate is a great team player passionate about bringing creativity and drive to solving scientific challenges and advancing research programs into development with strong technical, data generation, documentation, and presentation skills. 

Key Responsibilities:

This is a hands-on scientific role key to developing cutting-edge immunological assays and driving hit-to-lead and lead optimization programs with responsibilities that include: 

• Develop, establish, and perform immunological assays (cell culture, biochemical activity assays and flow cytometry) to support hit-to-lead (H2L) and lead optimization 
• Participate in conduct of in vivo studies including handling, injections, tissue collection and downstream assays 
• Generate and communicate high-quality, well-documented data to support real-time decisions  
• Proactively communicate project strategy, anticipate potential issues, and recommend appropriate resource decisions 
• Prioritize and coordinate research activities between internal staff and external contract research organizations (CROs) 
• Collaborate closely with team members across multiple disciplines to achieve project goals 

Qualifications:

The ideal candidate is as excited about the science as they are about Lifordi’s mission and brings: 

• Ph.D. in Biochemistry, Molecular Biology, Immunology or an equivalent scientific discipline, or MS with ≥4 years’ experience in a biotech/pharma 
• Proficiency in using a wide range of laboratory techniques including extensive experience in basic immunological techniques such as Th1/Th2 T cell assays, ELISA, flow cytometry, T/B/myeloid cell functional assays, and immune cell isolation 
• Experience with nucleic acid biology and the effect of nucleic acid manipulation (e.g., reporter assays, ASO or siRNA approaches and mutagenesis) 
• Knowledge of RNA therapeutics more broadly, RNA delivery, RNA/DNA design, and immunogenicity (a welcome plus) 
• Experience with in vivo studies including handling, tissue collection, and processing 
• High level of curiosity, willingness to problem-solve, high motivation to learn new skills, and excellent accountability and organization skills 
• High level of initiative in a small company environment including being a self-starter 
• Excellent communication and interpersonal skills 
• Experience working in dynamic, productive, cross-functional internal and external teams 
• Outstanding organizational abilities with a collaborative, tactful, and goal-oriented working style 

About Lifordi

Lifordi Immunotherapeutics, Inc. is a clinical-stage biotechnology company leveraging the success of antibody-drug conjugates (ADCs) for the treatment of autoimmune and inflammatory disorders. The Company’s lead ADC, LFD-200, is designed to deliver a potent glucocorticoid (GC) directly to immune cells and is in a Phase 1 clinical trial for rheumatoid arthritis (RA). Preclinical studies demonstrated efficacy in multiple disease models by targeting myeloid and lymphoid cells using a highly internalized cell surface membrane protein (VISTA). Lifordi has also applied its novel drug delivery platform to other diverse payloads, such as small molecules, antisense oligonucleotides (ASOs) and siRNA. As experienced drug developers in immunology and inflammatory diseases, together with expert clinical advisors, a strong partnering track record, and funding from ARCH Venture Partners, 5AM Ventures, Atlas Venture, and Sanofi Ventures, Lifordi is committed to changing how immune and inflammatory diseases are treated. 

For more information, please visit  www.lifordi.com .