senior product development scientist

GC Therapeutics

<div>
 
 
 Scientist / Senior Scientist &ndash; Cell Line Development
 
 
 
 
 
 
 
 Company Overview
 
 
 
 GC Therapeutics is the first genome-wide cell landscape exploration company using an integrated synthetic biology and AI-driven platform for cell programming. Its patent-pending and proprietary pluripotent stem cell di&fflig;erentiation technology platform TFome&trade; was developed in Professor George Church&rsquo;s lab, a pioneerin synthetic biology,and allows for the development of unique cell therapies with significantly streamlined manufacturing, improved cell quality, efficiency, and speed. GC Therapeutics is basedin Cambridge, MA. For additional information, please visitwww.gc-tx.com.
 
 
 
 
 
 
 Job Purpose
 
 
 
 GC Therapeutics is seeking a highly motivated Scientist or Senior Scientist to join our Cell Line Development (CLD) team. This role focuses on iPSC scale-up and differentiation from benchtop to production-scale bioreactors. The ideal candidate will engineer novel cell therapy products derived from human induced pluripotent stem cells (iPSCs) for regenerative and cell-based therapies and will contribute to the development of cell line candidates for early-phase clinical trials as part of a team developing iPSC derived cellular products and related quality control assays.
 
 
 
 
 
 
 Duties and Responsibilities
 
 
 <ul>
 <li>
 Culture iPSC lines including maintenance and analysis (e.g. cell culture, preparation of media, passaging, cryopreservation)
 </li>
 <li>
 Perform cell engineering on iPSCs to generate products for cell therapies.
 </li>
 <li>
 Design and execute experiments to optimize cell engineering processes for iPSCs and iPSC-derived cells .
 </li>
 <li>
 Perform, analyze and interpret experimental data, ensuring comprehensive documentation of methodologies and outcomes.
 </li>
 <li>
 Maintain a detailed laboratory journal, summarize results, and create presentations for meetings
 </li>
 <li>
 Troubleshoot iPSC cell line engineering challenges, improving process robustness for GMP readiness.
 </li>
 <li>
 Implement process changes for GMP compliance and support technology transfer to process development team.
 </li>
 <li>
 Contribute to the development of product characterization assays (e.g., identity, purity, potency, mechanism of action and functional assays).
 </li>
 <li>
 Draft and review batch records, SOPs and regulatory support documents for cell line engineering processes.
 </li>
 <li>
 Maintain accurate and complete records, ensuring compliance with documentation management systems.
 </li>
 <li>
 Collaborate with a multidisciplinary team including Analytical Development, Quality Assurance, Manufacturing, Operations, R&amp;D, etc.
 </li>
 </ul>
 
 
 
 
 
 Qualifications
 
 
 
 
 
 Essential Qualifications:
 
 
 
 <ul>
 <li>
 Advanced degree in cell biology, biochemical or biomedical engineering, cell therapy, or a related field with 2+ years of industry experience.
 </li>
 <li>
 Strong expertise in iPSC culture and maintenance, cell engineering, characterization of engineered cells, and cloning
 </li>
 <li>
 Hands-on experience with various cell type differentiation, characterization and experimental in-process and endpoint analysis including flow cytometry, ELISA and microscopy
 </li>
 <li>
 Significant experience with molecular biology tools for integration site and off-target analysis.
 </li>
 <li>
 Analyze differentiated cell products and establish QC metrics.
 </li>
 <li>
 Optimize, refine and scale differentiation protocols for candidate cell therapeutic products.
 </li>
 <li>
 Experience with documentation management systems
 </li>
 <li>
 Experience with working in the Controlled Non-classified Space.
 </li>
 <li>
 Knowledge of iPSC 2D and 3D cultures.
 </li>
 <li>
 Proficiency in quality management system and data analysis tools.
 </li>
 <li>
 Strong problem-solving, analytical, and documentation skills.
 </li>
 <li>
 Ability to work independently and collaboratively in a cross-functional team.
 </li>
 <li>
 Willingness to work outside normal hours including weekends to support lab activities as needed.
 </li>
 </ul>
 
 
 
 
 
 Additional Preferred Qualifications:
 
 
 <ul>
 <li>
 Experience with operations in GMP facilities and GMP guidelines.
 </li>
 <li>
 Experience in scale-up, process development using 3D culture, organoids and bioreactor systems.
 </li>
 <li>
 Proven track record and strong publications in stem cell or developmental biology.
 </li>
 <li>
 Knowledge of FlowJo, next generation sequencing (NGS), bioinformatics (R, Python).
 </li>
 <li>
 Expertise in genome integrity assessment and off-target characterization.
 </li>
 <li>
 Familiarity with automation, high throughput (HTP) imaging and cell cloning.
 </li>
 <li>
 Familiarity with relevant guidelines from the FDA, EMA and ICH.
 </li>
 </ul>
 
 
 
 
 
 Experimental Techniques:
 
 
 
 
 Cellular Biology:
 
 
 <ul>
 <li>
 Design and execute synthetic biology-based differentiation of iPSCs.
 </li>
 <li>
 Optimize, and scale iPSC derived differentiation for therapeutic cell products.
 </li>
 <li>
 Perform assays including Flow Cytometry, ELISA, ICC, cell-based assays and microscopy.
 </li>
 <li>
 Conduct DOE studies to optimize parameters affecting engineered iPSC growth and differentiation.
 </li>
 </ul>
 
 
 Molecular Biology:
 
 
 <ul>
 <li>
 Perform PCR, qPCR and ddPCR for cell characterization.
 </li>
 <li>
 Characterize target cells using next-generation sequencing (e.g., library preparation for bulk and single cell RNA-seq)
 </li>
 <li>
 Conduct genome integrity assessment and off-target characterization
 </li>
 </ul>
 
 
 General Laboratory:
 
 
 <ul>
 <li>
 Lead experimental design, data analysis, and presentation of results to team members.
 </li>
 <li>
 Maintain detailed and well-organized records of all experimental activities.
 </li>
 <li>
 Provide scientific and technical guidance to junior staff or contract manufacturing organizations (CMOs).
 </li>
 <li>
 Ensure compliance with GDP, GMP, safety regulations, and company policies.
 </li>
 <li>
 Stay current on scientific advancements and contribute to innovative research.
 </li>
 </ul>
 
 
 
 
 
 Pay Range
 
 
 
 $120,000 - $145,000
 
 
 (This range reflects the base salary only and does not include additional compensation such as annual bonus and equity awards, which are part of the total compensation package.)
 
 
 
 
 
 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
 
 
 
 
 
 At GC Therapeutics, our generous competitive benefits package also include generous PTO, paid holidays, Medical, Dental, Vision, 401(k), Life and Disability Insurance and transportation subsidy.
 
 
 
 
 
 
 Equal Opportunity Workplace:
 
 GC Therapeutics is an equal opportunity employer. We provide equal employment opportunities to all applicants for employment and existing employees without regard to ancestry, national origin, place of birth, race, color, gender, sexual orientation, marital status, pregnancy, religion, age, disability, gender identity, results of genetic testing, service in the military or otherwise to the full extent of all federal, state and local laws. GC Therapeutics&rsquo; equal employment opportunity policy applies to all terms and conditions of recruiting, hiring, placement, training, compensation, transfer, leave of absence, employment, promotion, layoff and termination of employment.
 
</div>

Scientist/Senior Scientist - Cell Line Development

Castle Biosciences, Inc.

<div>Castle Biosciences Earns &quot;Top Workplaces USA Award&quot; for Phoenix, Pittsburgh, and Friendswood!
You won't find a work culture and benefits package like ours every day. Come join our team and a group of colleagues who love working at Castle!
Learn more at www.CastleBiosciences.com
Castle Biosciences Inc. is growing, and we are looking to hire a R&amp;D, Senior Scientist, Pipeline working from our Pittsburgh, PA, @ Nova Place or Friendswood, TX office location, with a start date on or before December 1, 2025.
Why Castle Biosciences?
Exceptional Benefits Package:<ul><li>
Excellent Annual Salary
</li><li>20 Accrued PTO Days Annually + 10 Paid Holidays</li><li>
401K with 100% Company Match up to 6%</li><li>
3 Health Care Plan Options + Company HSA Contribution</li><li>
Company Stock Grant Upon Hire</li></ul>
A DAY IN THE LIFE OF AN R&amp;D Senior Scientist, Pipeline
The Senior Scientist, Pipeline, will work with R&amp;D colleagues to evaluate, develop, and validate clinical devices and molecular biomarkers that enhance disease diagnosis, prognosis, and prediction of therapy response. This role focuses on identifying opportunities for new clinical devices and tests, collaborating with cross-functional teams to develop business cases, project plans, and study protocols. The Senior Scientist will also support the Clinical Research team in organizing, auditing, and interpreting data from ongoing studies to build validity and utility evidence for current and pipeline tests. Additionally, this position will collaborate across Castle Biosciences to produce key scientific materials, including publications, abstracts, slide decks, and other literature used for internal training and external education.
REQUIREMENTS<ul><li>
Master's or PhD in life sciences or a bachelor's degree with a minimum of 3 years of postgraduate medical writing experience in life sciences or industry equivalent in the biotech sector.</li><li>
PhD level training in the life sciences, with a focus on oncology</li><li>
The ability to successfully communicate and teach in a complex and competitive environment.</li><li>
Strong interpersonal, organizational, and communication skills, written and oral.</li><li>
Demonstrated team player.</li></ul>
TRAVEL<ul><li>
10% travel required.</li></ul>
SCHEDULE<ul><li>
Monday - Friday, in-office 5 days a week from 9:00 am to 5:30 pm, exempt position, working from the Pittsburgh, PA @ Nova Place office or Friendswood, TX office occasionally.</li><li>
Off-hour work will be required to facilitate communication and meet deadlines.</li></ul>
READY TO JOIN OUR BIOTECH TEAM?
We truly appreciate your time. If this feels like the right opportunity for you, we'd love for you to complete our mobile-friendly application. We're excited to learn more about you and look forward to connecting soon!
Castle Biosciences Awards and Research Developments!
WORK AUTHORIZATION
All candidates must be legally authorized to work in the United States. Currently, Castle Biosciences does not sponsor H1B visas, OPT, or other employment-related visa's.
ABOUT CASTLE BIOSCIENCES INC.
At Castle, it all comes down to people. After all, disease doesn't just happen - it happens to people. We believe that disease management and treatment decisions can be better informed through a person's unique biology, which is revealed through the scientific rigor of our innovative, laboratory-developed tests. We are committed to empowering healthcare providers and patients with the goal of improved outcomes.
Every employee at Castle has an impact on patient care, and we work to ensure that everyone finds their work to be both challenging and rewarding. We behave with integrity and treat our colleagues with respect and kindness. Our culture fosters an environment of trust, transparency, and collaboration. We prioritize and encourage internal growth and professional development.
Castle Biosciences is an equal opportunity employer as to all protected groups, including protected veterans and individuals with disabilities.
If you have a disability and you believe you need a reasonable accommodation in order to search for a job opening or to submit an online application, please e-mail ReasonableAccommodationsRequest@castlebiosciences.com.
This email was created exclusively to assist disabled job seekers whose disability prevents them from being able to apply online. Only messages left for this purpose will be returned. Messages left for other purposes, such as following up on an application or technical issues not related to a disability, will not receive a response.
** No third-party recruiters, please</div>

Senior Scientist, Pipeline (PIT or FWD)

Amazon.com

<div><h2 class="jobSectionHeader">DESCRIPTION</h2><div>
Amazon&rsquo;s global talent is incredibly complex with unique problems to be solved for each line of business. Global Talent Management (GTM) is centrally responsible for managing and evolving Amazon&rsquo;s human capital through intelligent talent products and processes. GTM Science is a growing interdisciplinary science team within GTM that develops science products and services to facilitate Amazon&rsquo;s growth and development of talent across all of our businesses and locations around the world.
 
 
Our vision in GTM Science is to use machine learning and science to scalably solve organizational challenges focused on talent movement, talent differentiation, employee-role matching, promotion processes, organizational design and succession planning, diversity and inclusion, and new areas that address the evolving needs of our diverse employee base.
 
 
We are looking for an experienced machine learning scientist to work on talent science products that draw from a range of fields such as algorithmic fairness, natural language processing, supervised and unsupervised learning, recommendation systems, machine learning on graphs, reinforcement learning and others on rich and novel datasets. The role has high visibility to senior Amazon business leaders and involves working with other scientists, and partnering with engineering and product teams to integrate these models into production systems.
 
 
As an applied scientist in GTM Science, you will have the opportunity to work on exciting problems in one of the most innovative applications of science in the People Experience and Technology space. You will help to solve high impact business problems in an unconventional domain, and be encouraged to patent and publish your contributions. If this kind of work excites you, reach out to us to find out more!
 
 
Key Responsibilities
 
<ul><li>Design and implement models, science-based product ideas and features, project plans and communicate with stakeholders.
</li><li>Develop fair predictive models to understand important business and people-centered outcomes
</li><li>Productionize ML and science models at the scale of Amazon
</li></ul></div><h2 class="jobSectionHeader">BASIC QUALIFICATIONS</h2><ul><li>3+ years of building machine learning models for business application experience</li><li>PhD, or Master's degree and 6+ years of applied research experience</li><li>Experience programming in Java, C++, Python or related language</li><li>Experience with neural deep learning methods and machine learning</li></ul><h2 class="jobSectionHeader">
PREFERRED QUALIFICATIONS</h2><ul><li>Experience with modeling tools such as R, scikit-learn, Spark MLLib, MxNet, Tensorflow, numpy, scipy etc.</li><li>Experience with large scale distributed systems such as Hadoop, Spark etc.</li></ul> 
Amazon is an equal opportunity employer and does not discriminate on the basis of protected veteran status, disability, or other legally protected status. 
 
Our inclusive culture empowers Amazonians to deliver the best results for our customers. If you have a disability and need a workplace accommodation or adjustment during the application and hiring process, including support for the interview or onboarding process, please visit https://amazon.jobs/content/en/how-we-hire/accommodations for more information. If the country/region you&rsquo;re applying in isn&rsquo;t listed, please contact your Recruiting Partner. 
 
Our compensation reflects the cost of labor across several US geographic markets. The base pay for this position ranges from $150,400/year in our lowest geographic market up to $260,000/year in our highest geographic market. Pay is based on a number of factors including market location and may vary depending on job-related knowledge, skills, and experience. Amazon is a total compensation company. Dependent on the position offered, equity, sign-on payments, and other forms of compensation may be provided as part of a total compensation package, in addition to a full range of medical, financial, and/or other benefits. For more information, please visit https://www.aboutamazon.com/workplace/employee-benefits. This position will remain posted until filled. Applicants should apply via our internal or external career site.</div>

Sr. Applied Scientist , AMX Science

SUPRANATURALS, LLC

<div>POSITION PURPOSE AND SCOPE: 
This scientist will be responsible for developing formulas (liquid, powder, capsule), flavor work, and validating methods to support manufacturing and new products; instrumentation or equipment set up, troubleshooting, maintenance, and blend validation, and training other formulators in the lab.
 
 
ESSENTIAL RESPONSIBILITES:<ul><li>
Create new formulas for customers and formulate great tasting products</li><li>
Performs technical support for new product, to ensure product is ready for production run</li><li>
Creates the Batch Records for production runs.</li><li>
Troubleshoots any issues related to the materials of the product run</li><li>
Finds solutions to help machines run better for the product run</li><li>
Approves all changes to Batch Records</li><li>
Gather and compile supplier documentation.</li></ul> 

Note: This description is not intended to be all inclusive. Employee may be requested to perform other duties as requested.
 
 
EDUCATION AND EXPERIENCE:<ul><li>
Undergraduate degree in Food Science with 3-5 years experience in related field.</li><li>
Related manufacturing experience (5 years) primarily in formulation and flavor work.
<ul><li>We work with many pre-workout/energy brands, so experience working with caffeine is a plus.</li></ul></li></ul>
SKILLS AND ABILITIES:<ul><li>
Highly motivated, creative and independent performer with the ability to operate in a fast-paced, high pressure environment.
</li><li>Ability to interpret a variety of instructions furnished in written, oral, or schedule form.</li><li>
High ethical standards with the ability to maintain confidentiality of information.</li><li>
Excellent written and verbal communication skills.</li><li>
Strong analytical, critical thinking and communications skills.
</li><li>Ability to work both independently and in a team environment</li><li>
Must be able to follow all safety guidelines.</li></ul>
PHYSICAL DEMANDS: 
The employee may be required to lift and/or move up to 30 lbs. 
 
WORK ENVIRONMENT:<ul><li>
Laboratory environment which may include long hours standing, sitting, bending, twisting, walking, climbing stairs, strong and/or unusual odors.</li></ul> 

3Kqf7TA5Tp</div>

Product Development Scientist

Rich Products

<div>Rich&rsquo;s, also known as Rich Products Corporation, is a family-owned food company dedicated to inspiring possibilities. From cakes and icings to pizza, appetizers and specialty toppings, our products are used in homes, restaurants and bakeries around the world. Beyond great food, our customers also gain insights to help them stay competitive, no matter their size. Our portfolio includes creative solutions geared at helping food industry professionals compete in foodservice, retail, in-store bakery, deli, and prepared foods, among others. Working in 100 locations globally, with annual sales exceeding $4 billion, Rich&rsquo;s is a global leader with a focus on everything that family makes possible. Rich&rsquo;s&reg;&mdash;Infinite Possibilities. One Family.<div><div><div><h2 class="jobSectionHeader"> 
Purpose Statement</h2></div><div>
Rich Products, a $5.5Billion food manufacturing company, is looking for a Product Development Scientist II to join our growing R&amp;D Team. In this role, you will be responsible for new product development, product maintenance and product improvement for our desserts category. 
In this role, you will collaborate with cross functional teams to ensure successful development and commercialization of new products, product improvement or cost reductions. You will conduct routine, non-routine and complex research and development activities concerned with the chemical, biological and/or physical complexity of product formulations in order to develop new products and evaluate and improve the quality of existing products and related processes. 
You will successfully partner with others cross-functionally. 
This role is based in Missouri City, TX, with expected travel of 10%.</div></div><div><div><h2 class="jobSectionHeader">
Key Accountabilities and Outcomes</h2></div><div><div>
New Product Development/Product Improvements/Cost reductions 
<ul><li>Prepares prototype and line extension products using research lab, pilot lab, manufacturing facilities and equipment, as required. Typical project assignments involve small product line extensions and iterative new products (e.g. modifying a customized product formula to create a new product).</li><li>Plans, organizes and completes projects of modest scope or are a segment of a larger project. Selects and/or develops appropriate methods for conducting projects and assists in designing experiments.</li><li>Interfaces frequently with various internal departments (i.e. Marketing, Purchasing, Engineering) and customers in accomplishing project milestones.</li><li>Selects and evaluates raw materials for experiments.</li><li>Sets-up, operates and maintains research lab equipment.</li><li>Works with outside labs, universities, ingredient suppliers and lab equipment vendors as needed by project activity.</li><li>Designs and conducts complex shelf life and storage studies, including product and package performance under various conditions and makes recommendations for appropriate adjustments in product and/or package as required.</li><li>Designs and conducts storage studies, including product and package performance under various conditions.</li><li>Performs complex measurements and statistical analysis.</li></ul></div><div>
Technical Support 
<ul><li>Presents results of complex experiments and recommendations to various groups, both internally and externally.</li><li>Orders materials for producing and evaluating complex prototypes.</li><li>Develops solutions to a variety of technical problems of moderate scope and complexity by applying extensive technical knowledge and experience.</li></ul></div><div>
Record-keeping 
<ul><li>Maintains accurate, up to date records, laboratory notebooks and computer database.</li><li>Prepare and document all plant validation trials according to department protocol.</li><li>Ensures the work environment is sanitary, safe, and orderly.</li><li>Maintains a sanitary, safe and orderly work environment.</li></ul></div></div></div><div><div><h2 class="jobSectionHeader"> 
Knowledge, Skills, and Experience</h2></div><div><ul><li>Bachelor&rsquo;s Degree in Food Science, Food Engineering or related field with 3+ years product development related experience in food preparation/food industry; OR M.S.in Food Science, Food Engineering, or related field with 2+ years product development related experience in food preparation/food industry.</li><li>Demonstrated experience developing products such as cakes, cookies, muffins, brownies, icings/glazes.</li><li>Experience in applying advanced mathematics (i.e. statistics) and their practical application required.</li><li>Broad understanding of food science (e.g. biochemistry, microbiology, nutrition, etc.) acquired through both lecture and laboratory work.</li><li>Demonstrated ability to apply technical standards, principles, theories, concepts and techniques.</li><li>Solid verbal and written communication skills and presentation skills; with all levels within an organization.</li><li>Demonstrated ability to work in a fast paced environment.</li><li>Solid PC proficiency in Microsoft Office 365 including Word and PowerPoint; intermediate to advanced proficiency level in Excel and database, statistical software (spreadsheets, computer analysis; report writing). Proficient with relevant software tools (e.g. PLM, etc.) a plus.</li><li>Ability to use presentation and project management software beneficial.</li></ul> 
Physical requirements:<ul><li>Lift up to 50 lbs.</li><li>Stand for 6 or more hours during the work day.</li><li>Ability to compare and distinguish differences in ingredients, materials, etc. through taste, smell, touch and visual inspection.</li><li>Manual dexterity required to operate various equipment such as scales, balances, etc.</li></ul>
 #LI-NT1<h1 class="jobSectionHeader">
#CORP123</h1></div></div></div> 
COMPENSATION
In accordance with state law, the rate or range provided is Rich Products Corporation, its subsidiaries and affiliates (&quot;Rich's&quot;), reasonable estimate of the base compensation for this role. The actual amount may be higher or lower, based on non-discriminatory factors such as experience, knowledge, skills, abilities, shift differential, and location. 
Annual Range/Hourly Rate
$75,510.48 - $102,161.24 
Rich Products Corporation, its subsidiaries and affiliates (&ldquo;Rich&rsquo;s&rdquo;), are committed to a policy of Equal Employment Opportunity, standing up for fairness and maintaining a culture of belonging, to provide an exceptional experience for all. We will not discriminate against an applicant or employee on the basis of race, color, religion, sex, national origin, disability, military or veteran status, or any other Federal or State legally protected classes. The information collected by this application is solely to determine suitability for employment, verify identity, and maintain employment statistics on applicants. 
Applicants with disabilities may be entitled to reasonable accommodation under the Americans with Disabilities Act and certain state or local laws. A reasonable accommodation is a change in the way things are normally done which will ensure an equal employment opportunity without imposing undue hardship on Rich&rsquo;s. Please contact Rich&rsquo;s Associate Experience Network at hrhelp@rich.com if you need assistance completing this application or to otherwise participate in the application process.</div>

Product Development Scientist II

Guidant Global

Job Description Job Title: Senior Product Technologist - RTW (3-Month Contract) Start Date: Ideally by 15 November 2025 Contract Duration: 14 November 2025 - 27 February 2026 Day Rate: £164 - £240 (Umbrella) Location: SW1P 2AW, London (Fully office based) Overview: We are seeking an experienced Product Technologist or SENIOR PT to join our Ready-to-Wear (RTW) team on a 3-month contract. This role will provide hands-on technical support during a period of high workload across November, December, and January. The ideal candidate will bring strong multi-product RTW experience, with knowledge of knitwear being a distinct advantage. Key Responsibilities: <ul> <li>Support the RTW team across all stages, from raw material development through to industrialisation (bulk).</li><li>Help to reduce bulk production issues and drive improvements in product quality in line with company standards.</li><li>Identify and implement cost engineering opportunities.</li><li>Manage all fitting evaluations within the assigned RTW category, communicating amendments to manufacturers.</li><li>Oversee garment testing processes internally and with external laboratories.</li><li>Manage blocks and define constructional quality standards.</li><li>Ensure all products conform to relevant standards and safety regulations.</li><li>Maintain fit and quality consistency across collections.</li><li>Troubleshoot test failures and propose technical solutions that maintain product integrity and aesthetics.</li><li>Collaborate cross-functionally with Design, Product Development, Sourcing/Production, and Manufacturers.</li></ul> Context & Rationale: <ul> <li>This temporary position is required to relieve pressure on the existing team during a particularly demanding period, supporting key activities such as:</li><li>AU26 SRS reviews and production sign-off</li><li>Finalisation of the SU26 collection</li><li>Outlet and uniform proto fittings</li><li>Winter proto fittings</li><li>Kubix testing</li></ul>

Senior Product Technologist

Merck

<div>Job Description
Job Description:
Our Scientists are our Inventors. Through innovative thinking, state-of-the-art facilities, cutting-edge science, and technology, we collaborate to deliver the next medical breakthroughs. We are looking for a collaborative, self-motivated scientific leader with expertise in downstream bioprocessing to join Biologics Process Research &amp; Development (BPR&amp;D) as a Senior Principal Scientist.
BPR&amp;D within Research Laboratories is committed to rapidly delivering diverse biotherapeutics to patients by efficiently developing innovative and robust manufacturing processes and technologies. To achieve our goals, we work closely with colleagues in Discovery, Pre-clinical, Early Development, Analytical, Formulation, and Commercial Manufacturing, all within a diverse and inclusive environment. In addition to process development for pipeline biologics, we are focused on innovating and building next-generation biomanufacturing technologies. This includes investments in continuous manufacturing, green and sustainable processes, and proprietary technology platforms. We actively publish and engage with the scientific community to influence the field.
As a Senior Principal Scientist, you will drive various strategic initiatives and translate strategies into implementation for Biologics platform. You will collaborate with an immensely creative and collaborative team of scientists and engineers to design upstream, cell-culture processes while developing technical strategies related to upstream processing and recombinant expression of drug candidates in early- and late-stage development.
Responsibilities include, but are not limited to:<ul><li>
Serve as a scientific leader to shape and drive innovation across the Biologics pipeline, strategy, and science.</li><li>
Anticipate and solve scientific and technical challenges across projects and functional teams, in a fast-paced, multidisciplinary environment.</li><li>
Lead the development of robust and scalable upstream processes for biologics in various stages of clinical development, as well as process characterization and regulatory filings for successful commercialization.</li><li>
Improve upstream processes by increasing efficiency and cost-effectiveness through research and innovation, while evaluating technologies and industry best practices.</li><li>
Collaborate with academia, industry, and vendors to facilitate the development and early adoption of novel process technologies.</li><li>
Contribute to strategic initiatives; work with senior leaders to establish overall project strategy and guide teams in its execution.</li><li>
Conceptualize, plan, and execute projects using effective organizational, prioritization, and problem-solving skills.</li><li>
Stay updated on the scientific and regulatory landscape; contribute scientifically and build your reputation through conference participation.</li><li>
Represent BPR&amp;D as a upstream bioprocess expert/co-leader in internal and cross-functional project teams.</li><li>
Supervise, coach, and develop talent within the functional area; guide career development; build strong, collaborative teams.</li><li>
Champion compliance and safety while promoting a culture of diversity, equity, and inclusion.</li></ul>
Minimum Education Requirements:<ul><li>
Ph.D. with 10+ years, MS with 12+ years, or BS with 14+ years of industry experience in Chemical/Biochemical Engineering or a related field.</li></ul>
Required Experience, Skills, and Competencies:<ul><li>
Strong fundamental knowledge and subject matter expertise in cell-culture process development for biologics, fed-batch cell culture, bioreactor scale-up and scale-down, as well as recent advances, and challenges in the field</li><li>
Expertise in independently conducting and directing the design, execution, analysis, and documentation of all stages of cell-culture process development</li><li>
Track record of accomplishments in upstream bioprocessing with a history of peer-reviewed publications and presentations. Strong understanding of cell metabolism and biochemical pathways relevant to bioprocessing.</li><li>
Knowledge of biologics CMC development</li><li>
Ability to adapt to and prioritize complex objectives under tight timelines in a rapidly changing environment.</li><li>
Experience leading internal and external cross-functional, matrixed teams.</li><li>
Demonstrated scientific leadership with significant, measurable project impacts across a diverse set of programs.</li><li>
Action-oriented mindset with a capacity for creativity; ability to take initiative, innovate, iterate, and solve problems.</li><li>
Supervise, coach and mentor scientists to maximize talent development and utilization.</li><li>
Excellent interpersonal and communication skills.</li></ul>
Preferred Experience &amp; Skills:<ul><li>
Leadership of CMC development teams.</li><li>
Experience with continuous biomanufacturing integrated with process-analytical technologies.</li><li>
Intensified inoculum and perfusion process development</li><li>
Expertise in media/solution development and chemistry</li><li>
High-throughput experimentation, automation, and process control.</li><li>
Knowledge of microbial fermentation</li><li>
Cell culture predictive modeling (omics (transcriptomics, metabolomics, or/and proteomics), metabolic flux analysis); statistics, data-science, machine learning, artificial intelligence</li></ul>
PRD
Required Skills:
Biological Manufacturing, Biological Manufacturing, Biopharmaceutics, Bioprocess Engineering, Business, Cell Cultures, Cell Line Development, Cell Line Engineering, Clinical Judgment, Communication, Flux Analysis, Human Health Risk Assessment, Innovative Thinking, Interpersonal Relationships, Mammalian Cell Culture, Manufacturing Processes, Mentorship, Metabolomics, Molecular Biology, Omics Technologies, Process Characterization, Project Leadership, Project Management, Proteomics, Scientific Leadership {+ 3 more}
Preferred Skills: 
US and Puerto Rico Residents Only:
Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:
EEOC Know Your Rights
EEOC GINA Supplement
We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another&rsquo;s thinking and approach problems collectively.
Learn more about your rights, including under California, Colorado and other US State Acts
U.S. Hybrid Work Model
Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as &ldquo;remote&rdquo;.
The salary range for this role is
$187,000.00 - $294,400.00
This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee&rsquo;s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.
The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.
We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.
You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles&rsquo; Fair Chance Initiative for Hiring Ordinance
Search Firm Representatives Please Read Carefully 
Merck &amp; Co., Inc., Rahway, NJ, USA, also known as Merck Sharp &amp; Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status:
Regular
Relocation:
VISA Sponsorship:
Travel Requirements:
Flexible Work Arrangements:
Not Applicable
Shift:
Valid Driving License:
Hazardous Material(s):
Job Posting End Date:
11/21/2025<ul><li>A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date. 
</li></ul> 
Requisition ID:R351123</div>

Senior Principal Scientist, Upstream Process R&D

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