Advisor / Sr. Advisor – BioTDR Lead Optimization Mass Spectrometry

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Organization Overview:

Lilly’s Biotechnology Discovery Research (BioTDR) organization has a track record of discovering, optimizing, and delivering novel biotherapeutic medicines to the clinical for the treatment of unmet medical needs in diabetes, oncology, immunology, and neuroscience. This position is within the BioTDR Lead Optimization Group, and we seek a motivated scientist with experience in mass spectrometry and a working knowledge of the biotherapeutics discovery and development process to join our Team. The successful candidate will drive innovation within the Lead Optimization Group and work across the discovery and development interface to deliver Lilly’s early phase portfolio. Are you eager to drive innovation in a fast-paced, collaborative environment to develop life-changing medicines for patients? Our commitment to our employees, patients, and communities is unmatched, and we want you to be a part of our Team.

Responsibilities:

• Build mass spectrometry-based solutions for the characterization and developability assessment of a diverse and growing large-molecule portfolio, including monoclonal antibodies, bispecific antibodies, fusion proteins, antibody-drug conjugates, peptides, oligonucleotides, viral (e.g. AAV, lentivirus) and non-viral (e.g. LNP, liposome) genetic medicines, etc.

• Leverage extensive knowledge of and experience with a broad range of characterization methods to inform lead optimization (e.g., intact mass analysis, identification of post-translational modifications, profiling molecule assembly and structural variants including disulfide mapping, identifying glycosylation patterns, etc.)

Basic Requirements:

• Ph.D. in Analytical Chemistry, Biochemistry, Chemistry, or a related scientific field.

• Minimum 0-2 years of postgraduate academic, research institute, or industry experience.

• Proven experience in developing LC-MS-based methods for characterizing structural and chemical heterogeneity of proteins and peptides as supported by a strong publication record.

Additional Skills/Preferences:

• Working knowledge of the large-molecule drug discovery and development process, including developability assessment.

• Proficiency with various mass spectrometry platforms (e.g., Orbitrap, Q-TOF) and diverse software for data processing and analysis (e.g., Genedata Expressionist).

• Experience characterizing targeted lipid nanoparticles (tLNPs).

• Experience with mass spectrometry software/script development

• Familiarity with data science principles and best practices (e.g., FAIR data)

• Experience with automated HTP liquid handling systems for automated sample preparation

• Experience working with biological samples (e.g., serum, tissue)

• Collaborate with cross-functional teams, including protein engineers, chemists, and biologists, to support lead selection and optimization efforts through advanced analytical characterization.

• Strong verbal and written communication skills including the ability to share learnings across Team boundaries.

• Excellent time management and organizational skills with the ability to adapt to changing priorities and deadlines and thrive in ambiguity.

• Experience with notebooking and data analytics using Benchling.

• Promote a culture of safety and inclusion in the workplace, including coaching and mentoring peers and other scientists.

Additional Information:

• Location: Indianapolis, Indiana

• Travel: 0-10%

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$121,500 - $198,000

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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