Analytical Scientist - Anti Body Drug Conjugates

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At Veranova, we believe people are our most important asset, and we are dedicated to building the most talented workforce in our industry. Our commitment to uncompromising focuses on quality, compliance, safety, and excellence in delivery shapes everything we do. We are not just looking for skills; we are seeking innovative individuals who have a mindset open to learning and growth, and a desire to make a difference.

Veranova is a global leader in the development and manufacturing of complex active pharmaceutical ingredients (APIs) for pharma and biotech customers. With deep technical expertise and impressive flexibility, we develop solutions and processes that support and accelerate innovation.

Join us on our mission to enable current and next-generation therapeutics to improve and save the lives of patients.

Role Overview:

We are seeking a highly motivated and skilled Analytical Scientist to join our Analytical team in New England. The successful candidate will have expertise in LCMS (Liquid Chromatography-Mass Spectrometry) based characterization of complex bioconjugates, with a strong understanding of ADC structure and stability.

Core Responsibilities:

• Exercise technical judgment in the planning, implementation, and analysis of experiments related to method development, validation, reference standard creation and qualification, forced degradation, product characterization, and compatibility studies in accordance with pertinent ICH regulatory guidelines.
• Develop and optimize LCMS methods for qualitative and quantitative analysis of ADCs. Develop and validate quantitative LCMS methods such as:
  • Drug-to-Antibody Ratio (DAR) determination.
  • Payload quantification (free and conjugated forms).
  • Linker stability and degradation profiling.
  • Site-specific conjugation analysis.
• Perform intact mass analysis, peptide mapping, drug-to-antibody ratio (DAR) determination, and payload identification.
• Characterize ADCs for critical quality attributes including conjugation sites, linker stability, and degradation products.
• Author test methods, protocols, reports, and regulatory documents as needed.
• Provide support for development and cGMP manufacturing campaigns, ensuring compliance with regulatory requirements and documentation standards - including both in-process and release samples.
• Adhere to safety and quality standards.
• Communicate technical findings and results to both internal and external stakeholders, including clients and regulatory bodies.
• Collaborate with chemistry development scientists, quality control and regulatory affairs teams to ensure successful project delivery.
• Mentor and develop scientific staff. Ensure continued technical and professional growth of department members, encourage efforts towards excellence and knowledge sharing.
• Possess strong communication (oral, written), organizational, and leadership skills.
• Maintain and troubleshoot LCMS instrumentation (e.g., Orbitrap, Q-TOF, Triple Quad).

Qualifications:

Required

• Ph.D., M.S., or B.S. in Analytical Chemistry, Biochemistry, Chemistry, Chemical/Biomedical Engineering, or other related scientific discipline.
• Relevant experience in analytical method development, validation and characterization of bioconjugates. (PhD with 4+ years, MS with 6+ years, BS with 8 + years of experience.
• 4+ years of hands-on experience in LCMS analysis of biologics, preferably ADCs.
• Strong knowledge of protein chemistry, conjugation technologies, and biotherapeutic development.
• Proficiency in any of the software tools for MS data analysis (e.g., Xcalibur, MassHunter, Skyline, Biopharma Finder).
• Well organized with good problem-solving skills, a high level of attention to detail and have a passion for delivering high quality data in a fast-paced environment.

Preferred

• Experience with regulatory submissions and GMP/GLP environments.
• Experience with various techniques used in the characterization of ADC’s such as capillary electrophoresis (CE-SDS) for ADC purity and size analysis, hydrophobic interaction chromatography (HIC) for DAR profiling, size-exclusion chromatography (SEC) for aggregation and stability studies, UV-Vis spectroscopy and fluorescence-based assays for payload quantification, and immunoassays (ELISA, ECL) for antibody detection.

Our Commitment:

• Health & Wellness: Comprehensive health & Wellness benefits. Access to mental health resources and wellness programs. Generous PTO and holiday pay policies.
• Financial Wellness: Comprehensive total compensation package that includes competitive base salary, Defined Contribution Pension program, eligibility for performance-based bonuses, and attractive 401(k) Plan with company match.
• Professional Development: Opportunities for continuous learning through LinkedIn Learning, workshops, conferences, and mentorship. Tuition Assistance for Undergraduate and Graduate degree programs.
• Inclusive Culture: At Veranova, an inclusive culture is integral to our values. We are committed to ensuring that everyone can bring their full self to work and thrive in their career.

How to Apply:

At Veranova, we are on a misson to meet people that believe in our values and can contribute to the team in a variety of ways. Please visit www.veranova.com to view all open roles and join our Talent Community to stay connected and learn about opportunities as they arise.

We value a range of experiences and perspectives. If you want to be part of improving and saving the lives of patients, we encourage you to apply regardless of whether you meet every qualification listed.

For applicants who may require a reasonable accommodation for any part of the application or hiring process due to a disability, you may submit your request by sending an email to talentacquisition@veranova.com in order to confirm your request for an accommodation. Please include the job number, title, and location of role. This option is reserved for individuals who require accommodation due to a disability. Information received will be processed by a U.S. Veranova employee and then routed to a local recruiter who will provide assistance to ensure appropriate consideration in the application or hiring process.

Additional Information:

Applicants for this role must be authorized to work in the United States without further employer sponsorship.

Agency and Search Firm Representatives: Veranova does not accept unsolicited resumes from agencies and/or search firms for this job posting.

Important Notice Regarding Recruitment Scams: Veranova is committed to providing professional and secure recruitment experience for all applicants. Unfortunately, fraudulent job postings and recruitment scams are becoming more prevalent. We want to ensure that all candidates are aware of potential scams. Please see our notice here.

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• Veranova will never ask candidates for sensitive personal information during the application process (e.g., bank account details or social security number).
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All your information will be kept confidential according to EEO guidelines.

Veranova is an Equal Opportunity Employer. It is the policy of Veranova to provide equal employment access and opportunity to all persons regardless of age, race, color, national origin, religion, sex, sexual orientation, gender identity and/or expression, physical or mental disability, genetic information, citizenship, marital status, veteran status, or any other characteristic protected by federal, state, or local law.

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