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Bioinformatician and Data Infrastructure Lead
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When you join the growing BILH team, you're not just taking a job, you’re making a difference in people’s lives.
The Hide Laboratory at BIDMC and Harvard Medical School applies cutting-edge genomic and computational approaches to understand resilience and vulnerability in neurodegenerative disease. We seek a Bioinformatician / Data Infrastructure & Analytics Lead who will drive the lab’s computational strategy and data ecosystem. The successful candidate will establish lab-wide data standards, ensure reproducibility, and develop integrative analytic frameworks that support high-impact research, grant submissions, and translational discovery. The bioinformatician will manage and deliver developing code and pipelines for RNA-Seq, single-cell RNA-Seq, spatial transcriptomics, and proteomics profiling and also laboratory algorithm package maintenance and development. They will deploy a laboratory-wide data and work infrastructure. The successful candidate will be expected to take ownership of the lab’s data infrastructure, serve as a thought partner in experimental design and interpretation, and help shape the Hide Lab’s computational capacity for long-term success in cognitive resilience and neurodegeneration research
Job Description:
Essential Responsibilities:
- Leads projects associated with the design, development and maintenance of data collection instruments, databases and procedure manuals.
- Leads the design and implements, performs data management and quality control procedures as necessary for routine and special projects.
- Creates novel computational approaches and analytical tools as required by research goals
- Analyzes large molecular datasets such as raw microarray data, genomic sequence data, and proteomics data for clinical or basic research purposes
- Independently develops computational systems to allow comparison or integration of data from multiple sources. Supports the creation of such applications in support of research projects.
- Leads and collaborates with program staff on the design and analysis of biostatistics aspects of research protocols. Participates in the design of questionnaires and interview forms.
- Compiles data for use in activities such as gene expression profiling, genome annotation, and structural bioinformatics . Provides statistical and computational tools for biologically based activities such as genetic analysis, measurement of gene expression, and gene function determination
- Analyzes data beginning with univariate and multivariate analyses such as logistic regression and factor analysis for research studies. Supports the interpretation and assists in the creation of study results in collaboration with faculty members, epidemiologists, biostatisticians and other team members.
- Provides tabular and graphic summaries of analyses in a form suitable for inclusion in manuscripts for publication in peer reviewed scientific journals as well as for presentation at scientific meetings
- Travels to project specific administrative and or national clinical meetings and presents findings. Attends project team meetings as needed
- Has the authority to direct and support employees daily work activities. Has authority to undertake or recommend the following employment actions: hiring, termination, corrective action and performance reviews. Direct Reports: None Indirect Reports: None
- Assists in planning, monitoring and/or managing budget in functional area of department.
Required Qualifications:
- Doctoral degree in Computational Biology, Bioinformatics, or related field required.
- 5-8 years related work experience required in Integration of multiple complex NGS datasets including RNA-Seq, ChIP-Seq, ATAC-seq, CUT&RUN, and atlas-scale single cell/nucleus sequencing data and 1-3 years supervisory/management experience required
- Must be able to apply existing algorithms in the analysis of such data and, if necessary, derive novel programs. These include expertise in multivariable regression analyses, ChIP/ATAC peak calling, comprehensive motif analyses (discovery, enrichment, etc.), and single cell deconvolution and clustering
- Must have experience in performing bioinformatic analyses for a core, including acting as a liaison to core clients/users. Must have demonstrated facility in providing bioinformatic consultation, including translation of a user goals into a clear bioinformatic output. As such, should show evidence of authorship or attribution on multiple manuscripts
- Advanced skills with Microsoft applications which may include Outlook, Word, Excel, PowerPoint or Access and other web-based applications. May produce complex documents, perform analysis and maintain databases.
Preferred Qualifications:
- Advanced skills with Microsoft Excel, PowerPoint and other web-based applications. May produce complex documents, perform analysis and maintain databases.
- Specific skills using R/Bioconductor, Seurat, Picard, and CellBender preferred. Experience with online visualization tools for biological data, such as UCSC Genome Browser, Morpheus, and Single-Cell Portal.
- Should be able to clearly delineate and explain the goals, relative strengths/weaknesses of various possible computational algorithms to biologists without bioinformatic experience.
Competencies:
- Decision Making: Ability to make decisions that are guided by precedents, policies and objectives. Regularly makes decisions and recommendations on issues affecting a department or functional area.
- Problem Solving: Ability to address problems that are highly varied, complex and often non-recurring, requiring staff input, innovative, creative, and Lean diagnostic techniques to resolve issues.
- Independence of Action: Ability to set goals and priorities for functional area. May make recommendations for department policies, practices and programs. Manager or Director provides broad guidance and overall direction.
- Written Communications: Ability to summarize and communicate in English moderately complex information in varied written formats to internal and external customers.
- Oral Communications: Ability to comprehend and communicate complex verbal information in English to medical center staff, patients, families and external customers.
- Knowledge: Ability to demonstrate broad and comprehensive knowledge of theories, concepts, practices and policies with the ability to use them in complex and/or unprecedented situations across multiple functional areas.
- Team Work: Ability to act as a team leader for small projects or work groups, creating a collaborative and respectful team environment and improving workflows. Results may impact the operations of one or more departments.
- Customer Service: Ability to provide a high level of customer service and staff training to meet customer service standards and expectations for the assigned unit(s). Resolves service issues in the assigned unit(s) in a timely and respectful manner.
Physical Nature of the Job:
Sedentary work: Exerting up to 10 pounds of force occasionally in carrying, lifting, pushing, pulling objects. Sitting most of the time, with walking and standing required only occasionally
Pay Range:
$95,000.00 USD – $145,000.00 USD
The pay range listed for this position is the annual base salary range the organization reasonably and in good faith expects to pay for this position at this time. Actual compensation is determined based on several factors, that may include seniority, education, training, relevant experience, relevant certifications, geography of work location, job responsibilities, or other applicable factors permissible by law.
As a health care organization, we have a responsibility to do everything in our power to care for and protect our patients, our colleagues and our communities. Beth Israel Lahey Health requires that all staff be vaccinated against influenza (flu) as a condition of employment.
More than 35,000 people working together. Nurses, doctors, technicians, therapists, researchers, teachers and more, making a difference in patients' lives. Your skill and compassion can make us even stronger.
Equal Opportunity Employer/Veterans/Disabled
Job details
- Employment: Full-time
- Hours/Week: 40
- Shift: Day
- Category: Medical/Clinical Research
- Pay Range: $95,000.00 USD - $145,000.00 USD
- FLSA: Exempt
- Req ID: JR87474
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