Responsibilities
Reporting to the Dean of the Medical College, Pakistan, the
Director, Centre for Regenerative Medicine and Stem Cell Research is responsible for strengthening regenerative medicine and genomic research across AKU by training fundamental, translational and clinical researchers and leading translational research programmes.
The ideal candidate for the role:
The Director will be an inspirational leader who can develop and implement a strategic vision for the Centre. They will promote a culture of learning, innovation, collaboration, teamwork, respect and ethical conduct of research. The Director will strengthen relationships with researchers and clinicians across AKU and build a network of local and global partners, inclusive of academia, government research facilities, and industry. The Director will be a leader in AKU’s regions for policy development relative to regenerative and genomic medicine, ethics, commercialization opportunities, and community engagement.
The ideal candidate will work in domains of regenerative and genomic medicine that align with regional priorities for South Asia and East Africa, including Mendelian and complex disorders. The high rates of consanguinity in Pakistan enables the discovery of novel pathogenic variants for Mendelian diseases. The Centre/AKU facilities enable the development of iPSC and animal models targeting patient-specific variants, precise gene editing, investigation of signaling pathways, and drug testing. Together, these activities provide functional validation of disease-causing variants and mechanisms and enable therapeutic development. Conditions with regional significance include blood disorders (sickle cell anaemia / thalassemia), neurodevelopmental disorders, metabolic disorders, cancers, and retinal disorders. The ideal candidate will have experience in bench-to-bedside translation of cell or gene therapies in these regionally relevant domains.
This is a full-time position, with flexibility to consider a part-time arrangement for an exceptional candidate, in alignment with University policies.
Specific responsibilities will include to:-
lead interdisciplinary regenerative medicine research and training within the Medical College, Pakistan and AKU while strengthening local through international networks with a full range of stakeholders;
- leverage AKU assets, such as biobanks and longitudinal health outcomes and phenotype data for translational regenerative medicine research programmes;
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lead the development of cell and animal models to support foundational through translational research;
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develop strategies to build capacity for the clinical delivery of regenerative medicines, including cell and gene therapies by engaging Aga Khan University Hospital and its Clinical Trials Unit;
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ensure adequate space, capital and human resources are available to meet the research and manufacturing needs for clinical translation;
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ensure compliance with requirements of all regulatory and accrediting bodies;
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participate on external scientific and professional committees to enhance AKU’s reputation in regenerative medicine;
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represent AKU at international conferences, symposia and other professional convenings; apply for national and international grants to sustain and enhance the Centre’s strategic goals and research programmes;
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represent the Centre to donors in collaboration with the University Advancement team to enhance the operating endowment and other activities/positions/infrastructure.