Director, Quantitative Systems Pharmacology

Site Name: USA - Pennsylvania - Upper Providence, USA - Massachusetts - Cambridge
Posted Date: Oct 8 2025

Director, Quantitative Systems Pharmacology

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. We’re uniting science, technology, and talent to get ahead of disease together.
Find out more:
Our approach to R&D

Position Summary
We are seeking a motivated and experienced professional to join GSK as Director, Quantitative Systems Pharmacology (QSP). In this role, you will lead the development and application of QSP models to guide clinical study designs and provide mechanistic insights into study results. You will collaborate across multidisciplinary teams to advance our understanding of disease mechanisms and therapeutic strategies. This is an opportunity to make a meaningful impact on drug development while growing your career in a supportive and innovative environment.

Please note: This position requires an on-site office -based presence 2 to 3 days a week in the UK (London or Stevenage); Switzerland (Zug); US (Upper Providence, PA. or Waltham. MA); or Poland (Warsaw).

Responsibilities
This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:

• Develop and apply QSP models to inform clinical study designs and interpret study results.
• Collaborate with multidisciplinary teams to integrate QSP approaches into drug development strategies.
• Build and utilize models of biological and disease processes to evaluate drug candidates and treatment modalities.
• Translate QSP analyses into actionable insights and communicate findings effectively to project teams and stakeholders.
• Stay current with emerging modeling methodologies and contribute to the scientific community through publications and presentations.
• Lead and mentor other QSP modelers, fostering collaboration and innovation.

Basic Qualifications
We are seeking professionals with the following required skills and qualifications to help us achieve our goals:

• PhD in Applied Mathematics, Engineering, Pharmaceutical Sciences, or a related field.
• Experience in developing and applying QSP approaches in drug discovery and development.
• Proficiency in mathematical modeling, including ordinary differential equations and parameter estimation.
• Hands-on experience with modeling tools such as MATLAB, R, SimBiology, or similar platforms.
• Knowledge of regulatory guidelines and their application in clinical study design.
• Knowledge of pharmacokinetics, pharmacodynamics, and quantitative clinical pharmacology principles.
• Strong communication skills and ability to work collaboratively in multidisciplinary teams.

Preferred Qualifications
If you have the following characteristics, it would be a plus:

• Experience in oncology drug development or other therapeutic areas.
• Familiarity with advanced modeling approaches, such as mechanistic PKPD modeling or adaptive dosing simulations.
• Ability to summarize and present complex modeling outcomes to non-expert audiences.
• Demonstrated ability to innovate and contribute to scientific advancements in QSP.
• Strong leadership skills and experience mentoring junior scientists.

We encourage you to apply if you are passionate about advancing science and making a difference in patients' lives. Join us in uniting science, technology, and talent to get ahead of disease together.

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?
Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/