Post-Doctoral Research Fellow- Computational Medicine Center - Lab of Dr. Rigoutsos

Job Details

The position involves conducting research on short and long non-coding RNAs using analytical tools that integrate genomic, genetic, and transcriptomic datasets—both internally generated and publicly available. The primary focus is to elucidate the mechanisms underlying disease onset and progression, with particular emphasis on the role of non-coding RNAs in these processes. The role may also involve the development of novel analytical tools as needed.

Job Description

Job Summary

The position involves research focused on short and long non-coding RNAs, utilizing analytical tools that integrate genomic, genetic, and transcriptomic datasets—both internally generated and publicly available. The emphasis is on elucidating the mechanisms underlying disease onset and progression, with a particular focus on the role of non-coding RNAs in these processes. The role may also involve developing novel analytical tools to support the research objectives.

Essential Functions

PRIMARY FUNCTION :

• This position is responsible for conducting research in the field of non-coding RNAs using advanced analytical tools.

• The primary focus will be on elucidating the mechanisms underlying the onset and progression of disease, with an emphasis on the involvement of non-coding RNAs in these processes.

• Typical activities include software and tool development, tool testing, data analysis, and integration of data across multiple modalities.

Competencies (Knowledge, Skills, and Abilities Required):

• The candidate must have the requisite graduate-level knowledge base to effectively perform assigned and independent activities, including:

• Assist the PI in designing, implementing, and conducting analyses as required by the above-stated goals.

• Analyze data and report on research findings.

• Assist the PI in preparing novel research findings for publication in appropriate scientific journals and/or presentation to the scientific community at relevant scientific meetings.

• Demonstrate commitment to our core values of excellence and innovation, integrity and respect, teamwork, and communication.

• Know policies and procedures applicable to assigned duties.

• Use sound judgment and be aware of potential hazards before taking action.

• Promptly report errors/events or situations of actual or potential harm.

Education:

• Postdoctoral trainees must have received, as of the beginning date of the appointment, a Ph.D. in Biochemistry, Molecular Biology, Biomedical Engineering, Bioinformatics, Computational Biology, Computer Science, Electrical Engineering, or related field.

Experience:

• The ideal candidate should have familiarity with one or more of the following areas: computer science, machine learning, bioinformatics, and computational biology, and understand how these disciplines are applied to real-world problems in biology and medicine.
• Working knowledge of technical computing and software packages such as R, MATLAB, or similar tools for data analysis and visualization is expected.
• Experience in the field of non-coding RNAs, RNA interference, or related topics is strongly desired.
• A strong publication record is preferred.

Additional Information

The Rigoutsos lab is a highly dynamic and collaborative environment, as is the Computational Medicine Center at Thomas Jefferson University. The lab is at the cutting edge of biomedical research and pursues “data-driven basic science.” Central to the lab’s activities is the combination of experimental work (wet bench) with computational analyses of Big Data.

Research work in the Rigoutsos lab over the last 20 years has focused on short regulatory RNA molecules. The lab specifically studies three types of molecules in health and disease: the isoforms of microRNAs (miRNAs) that are known as isomiRs; the fragments of transfer RNAs (tRNAs) that are known as tRFs; and the fragments of ribosomal RNAs (rRNAs) that are known as rRFs.

The Rigoutsos lab is one of the leaders in this field and their work to date has led to several pioneering discoveries. The lab’s work frequently appears in high-impact factor journals, including Science , Nature , Nature Biotechnology , Nature Methods , Cell , Cancer Cell , Proceedings of the National Academy of Sciences (PNAS) , Nucleic Acids Research , Genome Biology , Genome Research , and Cancer Research .

The lab seeks motivated Postdoctoral Fellows to join and embark on an exciting journey to study these molecules and work towards unravelling their roles in the mechanistic events that underlie health and disease. The studies require advanced knowledge of genomic, biochemical, cell and molecular biology approaches, and modern computational techniques and analytical tools.

Work Shift

Workday Day (United States of America)

Worker Sub Type

Regular

Primary Location Address

1020 Locust Street, Philadelphia, Pennsylvania, United States of America

Nationally ranked, Jefferson, which is principally located in the greater Philadelphia region, Lehigh Valley and Northeastern Pennsylvania and southern New Jersey, is reimagining health care and higher education to create unparalleled value. Jefferson is more than 65,000 people strong, dedicated to providing the highest-quality, compassionate clinical care for patients; making our communities healthier and stronger; preparing tomorrow's professional leaders for 21st-century careers; and creating new knowledge through basic/programmatic, clinical and applied research. Thomas Jefferson University , home of Sidney Kimmel Medical College, Jefferson College of Nursing, and the Kanbar College of Design, Engineering and Commerce, dates back to 1824 and today comprises 10 colleges and three schools offering 200+ undergraduate and graduate programs to more than 8,300 students. Jefferson Health , nationally ranked as one of the top 15 not-for-profit health care systems in the country and the largest provider in the Philadelphia and Lehigh Valley areas, serves patients through millions of encounters each year at 32 hospitals campuses and more than 700 outpatient and urgent care locations throughout the region. Jefferson Health Plans is a not-for-profit managed health care organization providing a broad range of health coverage options in Pennsylvania and New Jersey for more than 35 years.

Jefferson is committed to providing equal educational and employment opportunities for all persons without regard to age, race, color, religion, creed, sexual orientation, gender, gender identity, marital status, pregnancy, national origin, ancestry, citizenship, military status, veteran status, handicap or disability or any other protected group or status.

Benefits

Jefferson offers a comprehensive package of benefits for full-time and part-time colleagues, including medical (including prescription), supplemental insurance, dental, vision, life and AD&D insurance, short- and long-term disability, flexible spending accounts, retirement plans, tuition assistance, as well as voluntary benefits, which provide colleagues with access to group rates on insurance and discounts. Colleagues have access to tuition discounts at Thomas Jefferson University after one year of full time service or two years of part time service. All colleagues, including those who work less than part-time (including per diem colleagues, adjunct faculty, and Jeff Temps ), have access to medical (including prescription) insurance.

For more benefits information, please click here