Postdoctoral Fellow-MSH-30030-279

Title: Postdoctoral Fellow

Salary: $75,796 per year

Department: Microbiology

Physical work location: One Gustave L. Levy Place Box #1124, NY, NY 10029

Name PI or Supervisor: Michael Schotsaert; michael.schotsaert@mssm.edu; 212-241-4847

Web link to Lab: https://labs.icahn.mssm.edu/schotsaertlab/

Web link to Dep’t: https://icahn.mssm.edu/about/departments/microbiology

Administrative Contact: Molly Deroy; molly.deroy@mssm.edu; 212-241-7318

Details of Research Project:

The postdoc will be involved in translational research projects that study host-pathogen interactions and host-vaccine responses in preclinical animal models. The research projects include work with guinea pigs, hamsters, mice and human primary cell cultures in BSL2/3/3+ facilities with SARS-CoV-2 and influenza virus. The aim of these studies is to find correlates of protection and understand host immune responses to viral infection and vaccination in different models. Special focus will be on immune profiling of mouse lungs in mice with skewed host immune responses upon respiratory infections. This work will be done at bio safety levels 2 (influenza virus) and 3 (SARS-CoV-2) in the lab.

Technical Duties:

• Hamster intranasal vaccination
• Adjuvant formulation and vaccine admixing
• Virus titration from nasal turbinates and lungs in preclinical animal models
• Setting up preclinical infection models with influenza virus and coronaviruses
• Serological assays (ELISA, microneutralization assays, ADCC assays, ADCP assays)
• Cellular mediated immunity assays (ELISPOT, flow cytometry)
• (Single cell) immune profiling (flow cytometry, single cell and bulk RNAseq, luminex cytokine ELISA, …) and assist with multi-OMICS data acquisition and analysis

Educational and other Requirements for the position: PhD required

Experience Required:

• Experience with handling mice in BSL2 environments.
• Sample preparation for OMICS data generation. E
• xperience with serological assays (ELISA) and single cell techniques (flow cytometry, RNA seq,… ).
• OMICs data analysis with standard analysis pipelines.

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About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

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Compensation

The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.