Postdoctoral Scientist - Protein Structure

CrossLife Technologies is a San Diego based Point of Care Diagnostics company who develop and commercialize novel diagnostics based on innovative nucleic acid technologies for many diseases. We are seeking a Postdoctoral Scientist – Protein Structure (full-time) position.

Key Responsibilities:

· Perform computational molecular design and modeling to inform and accelerate

the design and development of high quality, differentiated therapeutics

· Lead and support our internal, early portfolio of RNA, protein, gene and cancer

therapy programs.

· Contribute and participate in internal and external presentations, peer-reviewed

manuscripts and conference proceedings.

Qualification:

· PhD in Biomedical Engineering, Biochemistry, Computational Biology, Computer

Science, Structural Biology, Biophysics, Material Science, or other related

quantitative field is required.

· Experience in applied AI/ML or molecular modeling in drug discovery and

development including protein library design and selection is required.

· Experience with structural modeling of Protein-small molecules, protein–protein,

protein-DNA and protein-RNA interactions, protein and RNA folding is preferred.

· Experience in the development, evaluation and application of emerging AI/ML

methods (LMs, diffusion models, etc) for the design and optimization of RNA or

proteins is preferred.

· Experience using one of the following: Schrodinger, FoldX, Rosetta, Discovery

Studio, MOE, GROMACS, NAMD, or other molecular dynamics simulation

software, is required.

· Demonstrated ability to evaluate and deploy computational tools, algorithms and

platforms using internal and external datasets and benchmarks is required.

· Experience in the evaluation, design, development and deployment of molecular

models, algorithms and platforms across the enterprise in a cloud computing

environment (AWS, Azure, Google) is preferred.

· Hands-on experience in high performance scientific computing, software

engineering, deployment and scaling to the enterprise is required.

· Self-motivated individual, with experience working independently and as part of a

larger interdisciplinary team is required.

· Excellent communication, reporting and presentation skills and desire for

continuous learning and the ability to identify, evaluate and implement emerging

algorithms and models are required.

· Has a working knowledge of Biosimilar development ideally and must have an in-

depth knowledge of analytical techniques used for antibody/protein analysis

· Characterization of therapeutic proteins (recombinant proteins expressed in

eukaryotic and prokaryotic cells)

· Independent and thorough work on scientific projects and optimization of

existing methods (independent literature research, planning and execution of

experiments, evaluation and documentation of results)

Job Type: Full-time

Benefits:

• Dental insurance
• Health insurance
• Paid time off
• Retirement plan
• Vision insurance

Work Location: In person