Peptide Purification and Synthesis Scientist/Senior Scientist

We are seeking a highly motivated Scientist to join the Peptide Synthesis group at VidaVinci to establish and build a purification-specific function. This role offers a unique opportunity for an innovative and scientifically-driven individual to play a key role in high-throughput synthesis and purification of compound libraries to support both platform development and drug discovery programs. The ideal candidate for this role will have hands-on experience in peptide purification techniques, solid and liquid-phase peptide synthesis, implementation of enabling technologies, method development, and analysis of novel chemical matter. This is an on-site role in Watertown, MA.

Responsibilities

• Interface with synthetic and medicinal chemistry teams to address synthesis and purification challenges by implementing new techniques and instrumentation
• Interface with compound management to enable seamless access to the newly purified compounds to the corresponding stakeholders
• Establishing, implementing, and managing a purification workflow for novel peptides and complex small-molecules to support drug discovery programs
• Identify challenges and bottlenecks in methods and workflows and propose innovative solutions to increase throughput
• Evaluate status of peptide synthesis and purification capabilities and work with leadership to plan for equipment, software, and personnel needs
• Program, operate, maintain and troubleshoot automated synthesis and purification systems, HPLC, lyophilizers, rotovaps and other standard equipment
• Develop preparative HPLC methods and purify novel compounds
• Characterize newly synthesized compounds by LC-MS, NMR, circular dichroism or other analytical methods
• Use an ELN and LIMS to keep detailed records and register new compounds
• Coordinate across functions to plan synthesis projects, provide regular updates to stakeholders, and deliver high-quality compounds with a fast turnaround

Qualifications

• Scientist: PhD in Chemistry or a related field, including purification or separation of complex molecules, with 0-2 years of industry experience, or Master’s degree with 4+ years of relevant industry experience, or Bachelor’s degree with 8+ years of relevant experience
• Senior Scientist: PhD in Chemistry or a related field, including purification or separation of complex molecules, with 4+ years of experience, or Master’s degree with 8+ years of relevant experience, or Bachelor’s degree with 10+ years of relevant experience
• Experience in purification techniques, including HPLC (UV and MS-triggered) and SPE, experience with a variety of stationary phases, including normal, reverse, size-exclusion, and ion-exchange
• Experience in advanced analytical techniques such as CD, NMR, UV-VIS, FTIR
• Ability to work independently with minimal supervision and plan work autonomously
• Skills to supervise junior group members and communicate effectively with colleagues and senior leadership across disciplines
• Ability to manage time efficiently and meet ambitious deadlines
• Knowledge of lab safety standards and procedures
• Eager to solve problems and make a positive impact

Preferred Qualifications

• Experience in the synthesis of peptide libraries.