Research Technician II - Hematopoietic Cell Transplantation and Immuno-Oncology

Summary

The laboratory of Dr. Leo Luznik at Baylor College of Medicine is seeking a highly motivated and detail-oriented Research Technician II to join our translational research team. Our lab investigates the immune microenvironment in leukemia, with a focus on post-transplant immune reconstitution, T cell exhaustion, immune escape mechanisms, and novel immunotherapeutic strategies. We employ a range of cutting-edge techniques including single-cell multi-omics, in vivo leukemia models, and immunophenotyping platforms such as flow cytometry, CyTOF, and CITE-seq.

Job Duties

• Manages and maintains transgenic and immunocompromised mouse colonies, including genotyping, breeding, and induction protocols.
• Conducts bone marrow transplantation, T cell isolation, adoptive cell transfer, and in vivo drug treatments.
• Performs immune profiling using multicolor flow cytometry and assists in CyTOF and CITE-seq experiments.
• Prepares biological samples (blood, marrow, spleen, lymph nodes) for downstream molecular assays including RNA/DNA extraction, qPCR, and single-cell library prep.
• Assists with viral vector preparation and transduction protocols for immune and leukemia cell engineering.
• Maintains accurate laboratory records, organizes inventory, and supports regulatory compliance (IACUC, biosafety).
• Compiles experimental data and contributes to figures, lab reports, and scientific presentations.
• Coordinates with internal core facilities for sequencing, histopathology, and cytometry services.
• Assists in training students and new lab members as needed.
• Supports experiments outside of regular hours, including weekends.
• Performs other job-related duties as assigned.

Minimum Qualifications

• Bachelor's degree in a Basic Science or related field. Four years of related experience may substitute for degree requirement.
• Experience Required: None Required.

Preferred Qualifications

• Master's degree in basic science or a related field.
• At least 1 year of experience in an academic research lab working with murine models and/or immunologic assays.
• Experience in flow cytometry, cell isolation, and immune cell functional assays.