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Scientist II

Alameda, United States

Job Title: Scientist II

Location: Alameda , CA

Type: Contract

Compensation: 55-60/hr

Contractor Work Model: Onsite

Position Summary
We are seeking a highly motivated Temporary Scientist II to join our Preformulation and Solid-State Chemistry group within CMC Drug Product Development. The successful candidate will contribute to the characterization and development of small-molecule new chemical entities (NCEs), focusing on solid-state properties, preformulation assessments, and material sciences to support formulation design and drug product development. This is a temporary position with the opportunity to gain hands-on experience in a fast-paced, collaborative environment.

Key Responsibilities

Conduct preformulation studies to characterize the physicochemical properties of drug candidates (e.g., solubility, preclinical formulation (solution/ suspension), pKa, log P/D, hygroscopicity, stability).
Perform solid-state characterization using techniques such as XRPD, DSC, TGA, microscopy, FTIR, SEM, bulk/tapped density, contact angle, and solid-state NMR.
Under the guidance of a senior scientist, conduct salt, cocrystal, and polymorph screening to enable selection of optimal drug substance forms for development.
Conduct compatibility and excipient screening studies to support formulation development.
Work closely with formulation scientists to generate data guiding solid oral dosage form development.
Analyze, interpret, and document experimental data, ensuring high-quality technical reports.
Maintain laboratory notebooks and comply with all laboratory safety requirements.
Present data and findings in team meetings and contribute to scientific discussions.

Qualifications

Education & Experience

PhD/M.S. in Pharmaceutical Sciences, Chemistry, Materials Science, or related field with 0-2 years of relevant industry experience; or B.S. with 3-5 years of relevant experience in preformulation or solid-state chemistry.

Technical Skills

Hands-on experience with solid-state analytical techniques (XRPD, DSC, TGA, SEM, PLM, Surface area, True density, FTIR, HPLC, NMR spectroscopy).
Familiarity with solubility, dissolution, and stability testing of drug candidates.
Understanding of solid-state form screening (salt, cocrystal, polymorph).
Experience with data analysis and documentation in regulated environments.
Proficiency with scientific software and instrumentation for material characterization.

Other Skills

Strong problem-solving skills and scientific curiosity.
Excellent organizational and documentation practices.
Ability to work independently as well as in a multidisciplinary team environment.
Effective written and verbal communication skills.

System One, and its subsidiaries including Joulé, ALTA IT Services, and Mountain Ltd., are leaders in delivering outsourced services and workforce solutions across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan.

System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.

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Ref: #568-Clinical

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