Scientist/Sr. Scientist - Large Molecule Biology

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

As a scientist in the Large Molecule Biology group, you will be joining a large and dynamic group focused on executing experiments on the cutting edge of pharmaceutical sciences. You will execute experiments needed to support the various research programs for identified targets. You will oversee aspects of portfolio programs independently and with minimal direct oversight. You will be expected to demonstrate laboratory expertise with biologic assays aimed at drug development (mAb, ADC and CD3 platforms). In addition, assay development for specialized assays related to portfolio programs is required. You will also be encouraged to develop your own ideas and contribute these to the broader group. You are expected to be a dynamic and motivated scientist who can drive their own experiments and research activities, while collaborating extensively with the rest of the organization to execute on various research programs.

Job Responsibilities:

• Design and implement studies to identify, evaluate, and advance therapeutic candidates through the drug development pipeline.
• Demonstrate laboratory expertise with biologic assays aimed at drug development, specifically utilizing monoclonal antibodies (mAb), antibody-drug conjugates (ADC), and CD3 platforms.
• Manage the maintenance, culture, and passaging of multiple cell lines to support experimental objectives.
• Perform comprehensive functional assays and high-throughput screenings, including tumor cell signaling, internalization, cytotoxicity, effector function and cytokine release assays, to assess cellular responses.

• Conduct multi-parameter flow cytometry assays to determine binding interactions and accurately quantify receptor density across diverse cell populations.
• Conduct candidate evaluation in both in vitro (PK/PD, receptor occupancy, density, cytokine release), and ex vivo assays (tumor isolation, analysis of blood cells).
• Develop, validate, and perform bioanalytical assays—including ELISA—to precisely quantify proteins and antibodies relevant to experimental outcomes.
• Critically assess and monitor experimental procedures performed by third-party collaborators and vendors to ensure compliance with study protocols and quality standards.
• Work with the project leader and senior leader to design and execute assays for the development of the molecule.
• Present your work to internal teams and summarize findings in preclinical reports.
• Communicate results at project team meetings, be involved in the coordination and preparation of presentations.
• Discuss results with technical as well as non-technical personnel.
• Work in cross functional environments via extensive collaboration with other parts of the organization.

Basic Requirements:

• Bachelors degree in biological sciences or related scientific field with 5+ years of experience or Master’s in biological sciences or related scientific field with 2+ years of experience.

Additional Skills/Preferences:

• Experience with mammalian cell culture
• Extensive expertise performing in vitro, and ex vivo assays
• Strong data analysis skills with attention to detail
• Ability to design comprehensive experimental plans and carry out in a timely fashion
• Deep expertise in cancer disease states (indications, mutational status, tumor cell drivers)
• Demonstrated experience in working collaboratively across various scientific disciplines to meet end goals of business
• Excellent communication and interpersonal skills
• Demonstrated ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$71,250 - $187,000

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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