principal scientist 2 - preclinical safety Jobs in Hyderabad

principal scientist 2 - preclinical safety

principal scientist | t-cell immunology Jobs in Hyderabad

principal scientist | t-cell immunology

scientist - pharmaceutical development Jobs in Hyderabad

scientist - pharmaceutical development

senior principal scientist – discovery chemistry Jobs in Hyderabad

senior principal scientist – discovery chemistry

principal scientist t cell immunology

PopVax

<div>
 PopVax is an Indian full-stack biotech building first-in-class and best-in-class vaccines and cancer immunotherapies using machine learning-driven design and relentless empiricism. We design, develop, and manufacture our own RNA medicines end-to-end because we believe great pharmaceutical science can only flourish in tight feedback loops that iterate rapidly. PopVax&rsquo;s experimental work and clinical dose production is based at the RNA Foundry, our integrated R&amp;D and GMP-capable clinical dose production facility in Hyderabad.
 
 
 PopVax's north star is our goal of developing novel vaccines and therapeutics over the next decade with the cumulative ability to save 1 million lives each year &ndash; the Million Lives Mission. To that end, we are developing first-in-class vaccines against Hepatitis C Virus, Strep A, and adult pulmonary TB, broadly-protective best-in-class vaccines against COVID-19, influenza, and HPV, and precision immunotherapies against hard-to-treat solid tumours such as liver cancer and pancreatic cancer.
 
 
 Our work is funded by Vitalik Buterin&rsquo;s Balvi Fund, the Gates Foundation, the US Biomedical Advanced Research and Development Authority (BARDA), and Renaissance Philanthropy. Our first vaccine program will begin a Phase I clinical trial in the US in mid-2026 conducted &amp; sponsored by the National Institutes of Health (NIH). We intend to put 6 novel vaccines and immunotherapies into Phase I clinical trials over the next 3 years.
 
 
 No matter the job title, each person&rsquo;s role at PopVax is ultimately focused on helping take safe &amp; effective new medicines that represent a step-change improvement on the current standard-of-care to the people who need them as fast as possible. If you want to work where the ambition is high, the learning curve is steep, and the work matters to billions, you&rsquo;ll feel at home here.
 
 
 If you&rsquo;re excited by the idea of advancing scientific, clinical, and regulatory frontiers of vaccines and immunotherapies, spending each day developing medicines with the potential to save millions of lives, and building a generational global pharmaceutical company in India along the way &ndash; join us!
 
 
 We are seeking an exceptional, experienced senior immunologist with specific expertise in T-cell biology, hands-on experience with T-cell isolation, stimulation and enrichment protocols, in-depth knowledge of TCR discovery, and assays related to measuring T-cell potency and cytokine release.
 
 
 
 Responsibilities
 
 
 
 <ul>
 <li>
 Maintenance and handling of primary immune cells from various sources
 </li>
 <li>
 Contribute to the design of TCRs and TCR-mimics
 </li>
 <li>
 Lead discovery campaigns to generate TCRs via stimulation assays (medium throughput or high throughput fashion)
 </li>
 <li>
 Plan and execute in vitro and in vivo experiments to comprehensively characterise the potency of both designed and discovered TCRs.
 </li>
 <li>
 Lead communication and drive collaboration between the immunology and the antigen design, mRNA, and formulation teams
 </li>
 <li>
 Develop study outlines, detailed timelines and oversee the logistics for execution of parallel and staggered experiments
 </li>
 <li>
 Ensure effective and thorough documentation, analysis, and interpretation of the experimental data generated by the immunology team
 </li>
 <li>
 Mentor juniors and lead a team to take independent decisions for experimental designs
 
 
 </li>
 </ul>
 
 Qualifications
 
 
 
 <ul>
 <li>
 PhD and 8+ years or Masters and 10+ years of experience in immunology, biochemistry, life sciences, or a related discipline, with a minimum of 5 years of experience in TCR discovery and development in academia or industry
 </li>
 <li>
 Experience in performing and in-depth understanding of routine immunology techniques such as ELISA, ELISPOT, multiplex assays, and multi-colour flow cytometry, including intracellular cytokine staining
 </li>
 <li>
 In-depth understanding of T-cell biology, and downstream therapeutics, including CAR-T and T-cell engagers
 </li>
 <li>
 Familiarity with data analysis software such as FlowJo and Prism
 </li>
 <li>
 Strong written and oral communication skills
 </li>
 <li>
 A proven track record of research publications and, ideally, presentations at research conferences
 </li>
 <li>
 Proven leadership and mentorship experience in pre-clinical research and development
 
 
 </li>
 </ul>
 We offer very competitive compensation, comprehensive health insurance covering immediate family (including pre-existing conditions), and, most importantly, a collaborative work environment focused on solving the cutting-edge multidisciplinary challenges of our novel mRNA platform.
</div>

Principal Scientist | T-cell immunology

PI Health Sciences Ltd

<div>
 
 
 
 Role - Research Scientist - In Vitro ADME
 
 
 
 
 
 
 
 
 Educational Qualifications
 
 
 <ul>
 <li>
 Master&rsquo;s degree in pharmacology, Biochemistry, Pharmaceutical Sciences, or related discipline.
 </li>
 <li>
 5&ndash;7 years of direct experience in an in-vitro ADME laboratory (pharma/biotech/CRO).
 </li>
 </ul>
 
 
 
 
 
 
 Purpose:
 
 
 
 
 To generate high-quality, reproducible in-vitro ADME data that supports medicinal chemistry and discovery biology teams in optimizing molecular properties. The role ensures robust ADME assay execution, scientific interpretation, innovation in assay methodologies, and effective cross-functional collaboration to accelerate hit-to-lead and lead optimization programs.
 
 
 
 
 
 
 Key Responsibilities
 
 
 
 
 
 
 
 A. Strategic Responsibilities
 
 
 <ul>
 <li>
 Provide strategic ADME insights to Medicinal Chemistry and Biology for compound prioritization.
 </li>
 <li>
 Influence project direction by interpreting trends in clearance, permeability, solubility, DDI risk, and transporter interactions.
 </li>
 <li>
 Contribute to defining the ADME package for hit-to-lead, lead optimization, and early preclinical milestones.
 </li>
 <li>
 Identify and introduce emerging ADME assay technologies, automation opportunities, and predictive tools (e.g., IVIVE, ADMET modelling).
 </li>
 <li>
 Support long-term capability building of the DMPK platform.
 </li>
 </ul>
 
 
 
 
 
 B. Operational Responsibilities
 
 
 <ul>
 <li>
 Independently design, execute, and troubleshoot in-vitro ADME assays such as metabolic stability, plasma stability, protein binding, CYP inhibition/induction, phenotyping, PAMPA, Caco-2, MDCK, transporter assays, solubility, and DDI workflows.
 </li>
 <li>
 Analyse and interpret LC-MS/MS data to calculate intrinsic clearance, permeability coefficients, efflux ratios, enzyme contributions, and stability parameters.
 </li>
 <li>
 Maintain meticulous documentation through ELNs, assay worksheets, and technical reports.
 </li>
 <li>
 Coordinate with cross-functional teams for sample management, study timelines, and data delivery.
 </li>
 <li>
 Maintain lab infrastructure including LC-MS/MS, automation systems (TECAN), incubators, and cell culture platforms.
 </li>
 <li>
 Support assay validation, SOP drafting, and continuous improvement initiatives.
 </li>
 </ul>
 
 
 
 
 
 C. Financial Responsibilities
 
 
 <ul>
 <li>
 Optimize usage of consumables, enzymes, reagents, plates, and solvents to minimize assay costs.
 </li>
 <li>
 Ensure efficient LC-MS/MS run scheduling to maximize instrument throughput and reduce operational overheads.
 </li>
 <li>
 Contribute to budgeting for ADME assays, method development projects, and instrument maintenance needs.
 </li>
 <li>
 Avoid repeat experiments through strong assay robustness and error-free execution.
 </li>
 </ul>
 
 
 
 
 
 D. People Responsibilities
 
 
 <ul>
 <li>
 Mentor junior team members on ADME assay execution, data analysis, and instrument handling.
 </li>
 <li>
 Foster a culture of scientific rigor, collaboration, and knowledge sharing across the discovery teams.
 </li>
 <li>
 Provide training on new assays, safety practices, LC-MS/MS operations, and automation tools.
 </li>
 <li>
 Demonstrate collaboration with Medicinal Chemistry, Biology, and PK/PD teams by ensuring timely delivery of ADME insights.
 </li>
 </ul>
 
 
 
 
 
 E. Risk &amp; Compliance Responsibilities
 
 
 <ul>
 <li>
 Ensure adherence to internal SOPs, quality standards, and audit requirements.
 </li>
 <li>
 Follow all safety guidelines related to chemical handling, biohazards, waste disposal, and lab operations.
 </li>
 <li>
 Conduct periodic instrument checks, calibration, and preventive maintenance to avoid operational risks.
 </li>
 <li>
 Maintain strict data integrity (ALCOA+), traceability, and documentation discipline.
 </li>
 <li>
 Flag scientific, operational, or compliance risks (e.g., assay drift, QC failures) proactively.
 </li>
 </ul>
 
 
 
 
 
 
 
 
 3. Behavioural Competencies
 
 
 
 (Aligned with PI Industries / PIHS leadership attributes&mdash;Curious, Creative, Courageous, Caring)
 
 
 
 1. Scientific Curiosity
 
 
 <ul>
 <li>
 Continuously explores new techniques, ADME tools, predictive modelling, and literature.
 </li>
 </ul>
 
 
 2. Collaboration &amp; Cross-Functional Partnership
 
 
 <ul>
 <li>
 Works seamlessly with Chemistry, Biology, Toxicology, and PK/PD teams.
 </li>
 <li>
 Communicates data clearly, proactively, and purposefully.
 </li>
 </ul>
 
 
 3. Problem-Solving &amp; Analytical Thinking
 
 
 <ul>
 <li>
 Identifies root causes in assay performance issues and proposes smart solutions.
 </li>
 </ul>
 
 
 4. Planning &amp; Execution Discipline
 
 
 <ul>
 <li>
 Delivers consistent, high-quality data within agreed timelines.
 </li>
 <li>
 Manages workload in a fast-paced discovery environment.
 </li>
 </ul>
 
 
 5. Ownership &amp; Accountability
 
 
 <ul>
 <li>
 Takes responsibility for experiment design, execution, reporting, and data integrity.
 </li>
 </ul>
 
 
 6. Innovation Orientation
 
 
 <ul>
 <li>
 Suggests process improvements, new assays, automation enhancements, and efficiency tools.
 </li>
 </ul>
 
 
 7. Compliance Mindset
 
 
 <ul>
 <li>
 Adheres to SOPs, safety standards, documentation rules, and audit expectations.
 </li>
 </ul>
 
 
</div>

Pharmacologist

Hetero

<div>
 JD:
 
 
 <ul>
 <li>
 Launch Strategy &amp; Planning:
 </li>
 <li>
 Drive go-to-market strategies for new products along with respective countries and HO marketing teams
 </li>
 <li>
 Define clear launch milestones, timelines, and deliverables in alignment with business objectives.
 </li>
 <li>
 Lead launch readiness assessments at key intervals (T-12/T-6/T-3 months).
 </li>
 <li>
 Develop key performance indicators (KPIs) to measure launch success and ensure continuous improvement.
 </li>
 <li>
 Cross-Functional Governance &amp; Alignment
 </li>
 <li>
 Lead cross-functional launch governance forums; synchronize country teams, commercial leadership, regulatory planning, and supply strategies.
 </li>
 <li>
 Facilitate alignment between HQ brand strategy and country-level execution realities.
 </li>
 <li>
 Navigate cross-border launch dependencies (filed vs. approved markets, staggered sequencing).
 </li>
 <li>
 Influence without authority, ensuring functional accountability and transparency.
 </li>
 <li>
 Launch Project Management:
 </li>
 <li>
 Own the complete lifecycle of new product introductions across multiple markets simultaneously.
 </li>
 <li>
 Deploy standardized project management tools for tracking status, risks, mitigation plans, and scenario sensitivity.
 </li>
 <li>
 Ensure timely delivery of regulatory milestones, product artworks, pricing approvals, supply readiness, and commercial materials.
 </li>
 <li>
 Drive launch critical path management and escalate deviations proactively.
 </li>
 <li>
 Market Readiness &amp; Execution:
 </li>
 <li>
 Ensure timely deployment of localized marketing assets, brand messaging, scientific narratives, digital content, and sales enablement kits.
 </li>
 <li>
 Coordinate competency-based field force training with Medical/Marketing.
 </li>
 <li>
 Prepare pricing, positioning, value statements, and competitive objection-handling guides.
 </li>
 <li>
 Post-Launch Evaluation:
 </li>
 <li>
 Analyze post-launch performance and gather feedback from sales teams, customers, and other stakeholders.
 </li>
 <li>
 Assess the launch&rsquo;s success against predefined KPIs, including sales performance, market penetration, and customer feedback.
 </li>
 <li>
 Conduct structured post-launch reviews at 30/60/90/180 days.
 </li>
 <li>
 Identify areas for improvement and implement post-launch optimization strategies.
 </li>
 <li>
 Portfolio &amp; Pipeline Visibility
 </li>
 <li>
 Maintain forward-looking transparency on the regional launch pipeline (12&ndash;36 months).
 </li>
 <li>
 Provide launch prioritization guidance based on market attractiveness, competitive timing, and channel constraints.
 </li>
 <li>
 Support portfolio scenario planning, sequencing, and cannibalization risk assessment.
 </li>
 <li>
 Continuous Improvement:
 </li>
 <li>
 Lead initiatives to improve the new product launch process, incorporating best practices, technology, and learnings from previous launches.
 </li>
 <li>
 Provide leadership in developing tools, templates, and processes that enhance launch efficiency and effectiveness.
 </li>
 <li>
 Foster a culture of excellence and innovation, continuously striving to improve the company&rsquo;s product launch capabilities
 
 
 </li>
 </ul>
 Strategic thinking with rigorous execution discipline
 
 
 <ul>
 <li>
 End-to-end ownership mindset
 </li>
 <li>
 Data-driven decision making
 </li>
 <li>
 Cross-functional orchestration finesse
 </li>
 <li>
 High comfort with ambiguity and shifting timelines
 </li>
 <li>
 Cultural agility across diverse geographies
 </li>
 </ul>
</div>

Hiring for Sr.Manager - NPL(NewProduct Launch)-International Marketing

Novartis India

<div>
 
 Summary
 
 
 
 The Preclinical Safety (PCS) department within the Novartis Biomedical Research - Translational Medicine Unit provides non-clinical safety strategy of products in -discovery, -development and -market, globally, with state-of-the-art regulatory compliance.
 
 
 As a Principal Scientist-2, you will join our PCS team in India to discuss strategies and deliver non-clinical safety deliverables for the products you are globally responsible for. This role also involves development and review of nonclinical scientific submission components (eCTD module 2.4 and 2.6) and other lifecycle management regulatory documents for multiple projects.
 
 
 
 About The Role
 
 
 
 Key Responsibilities
 
 :
 
 
 
 <ul>
 <li>
 Strategy and delivery of PCS deliverables for products under development and in-market.
 </li>
 <li>
 Independently provide PCS inputs in PSURs, DSURs, annual reports, registrations, renewals and label updates for the delegated products.Addresses regulatory queries on delegated products.
 </li>
 <li>
 Conducts literature searches and analyzes relevant non-clinical safety data and decide benefit-risk of new nonclinical information in collaboration with patient safety experts.
 </li>
 <li>
 Contribute to the objectives and deliverables of (Global Project Team) in cross-functional collaboration with other GPT representatives.
 </li>
 <li>
 Evaluates the toxicological profiles of impurities, degradants and assess the specification limits based on ICH guidelines.
 </li>
 <li>
 Provides to nonclinical scientific writing support fo regulatory submission documents such as, IB, IND/CTA, NDA/BLA/MAA and Health Authority briefing books.
 </li>
 <li>
 Organizes nonclinical scientific activities and timelines in collaboration with authors for planned submission to meet strategic objectives of nonclinical submission deliverables.
 </li>
 <li>
 Develop expertise in internal Document management system to facilitate timely completion of projects and meet compliance requirement.
 </li>
 <li>
 Act as a nonclinical scientific liaison to Submissions &amp; Documentation (S&amp;D) vendor supporting nonclinical submission document management.
 </li>
 <li>
 Ensure that all the activities and deliverables are compliant with Novartis animal welfare policies, in-house standard operating procedures, Novartis expert recommendations (where feasible) and all relevant international regulatory guidelines/regulations.
 </li>
 <li>
 Be a team player and support local implementation of Preclinical safety strategies and independently contribute to multidisciplinary project/program goals within the Preclinical safety team. Communication skill is critical to this role in forming strong working relationships with team members and across functional disciplines.
 
 
 </li>
 </ul>
 
 Essential Requirements
 
 
 
 <ul>
 <li>
 PhD in life sciences with 6+ years experiences in drug discovery, drug development and/or life cycle management studies with an exceptional understanding of nonclinical submission writing
 </li>
 <li>
 In-depth knowledge of toxicology and preclinical safety assessment, understanding of drug metabolism and pharmacokinetics / pharmacodynamics, experience working in project teams, and knowledge of drug development and regulatory environment
 </li>
 <li>
 Understanding of GLP principles in nonclinical studies and submission writing.
 </li>
 <li>
 Proficient with full range of techniques used in job and core areas. Working knowledge of tools and processes used in drug design and development.
 </li>
 <li>
 Extensive library research skills and knowledge of problems-solving techniques; publication and presentation experience preferred.
 </li>
 <li>
 Excellent communicators, strong team players and have a high level of logistical/planning ability.Strong written and verbal capabilities in English preferred.
 </li>
 <li>
 Registration and certification with one of the International Toxicology registers.
 
 
 </li>
 </ul>
 
 Desirable Requirement
 
 
 
 <ul>
 <li>
 Animal Models ,Communication Skills, Data Analysis.
 </li>
 <li>
 Ethics ,Laboratory, Problem Solving.
 </li>
 <li>
 Regulatory Compliance.
 </li>
 <li>
 Research.
 </li>
 <li>
 Risk Assessment.
 </li>
 <li>
 Toxicology.
 
 
 </li>
 </ul>
 Commitment to Diversity &amp; Inclusion: :
 
 
 
 We are committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.
 
 
 
 Why Novartis: Our purpose is to reimagine medicine to improve and extend people&rsquo;s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our
 
 
 people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture
 
 
 You&rsquo;ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook. https://www.novartis.com/careers/benefits-rewards
 
 
 
 Commitment To Diversity And Inclusion
 
 
 
 Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.
 
 
 Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network.
 
 
 
 Why Novartis:
 
 Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients&rsquo; lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture
 
 
 
 Benefits and Rewards:
 
 Read our handbook to learn about all the ways we&rsquo;ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards
</div>

Principal Scientist 2 - Preclinical Safety

Golden Opportunities

<div>
 
 Job Description
 
 
 
 Define, build, and lead a team of Data Scientists and Data analysts Discover areas in operations that can be automated through machine learning Demonstrate through technical knowledge on Statistical modeling, Probability and Decision theory, Operations Research techniques and other quantitative modeling techniques Understand the business reality behind large sets of data and develop meaningful solutions comprising of analytical solutions Work closely with internal stakeholders and align them with respect to your focus area Innovate by adapting new modeling techniques and procedures Implementing and operating stable, scalable data flow solutions from production systems into end-user facing applications/reports.
 
 
 
 Skills Required
 
 
 
 RoleData Scientist
 
 
 Industry TypeIT/ Computers - Software]
 
 
 Functional AreaIT-Software
 
 
 Required Education
 
 
 Employment TypeFull Time, Permanent
 
 
 Key Skills
 
 
 <ul>
 <li>
 DATA SCIENCE
 </li>
 <li>
 MACHINE LEARNING
 
 
 </li>
 </ul>
 Other Information
 
 
 Job CodeGO/JC/1384/2025
 
 
 Recruiter NameRamya V
</div>

Data Scientist - GO/JC/1384/2025

Microsoft

<div>
 
 Overview
 
 
 
 We are seeking a passionate and technically skilled Data Scientist II to join the Commerce &ndash; Platforms, Data, and Experiences (PDX) team. This team plays a pivotal role in shaping Microsoft&rsquo;s commerce data strategy, building scalable data platforms, and delivering actionable ML driven insights that drive business transformation across the ecosystem.
 
 
 As a Data Scientist II in PDX, you will work at the intersection of data engineering, data processing, and machine learning to solve complex business problems. You will collaborate with cross-functional teams to design experiments, build predictive models, and develop scalable solutions that enhance decision-making and customer experiences by producing descriptive, diagnostic, predictive and prescriptive insights.
 
 
 
 Responsibilities
 
 
 
 <ul>
 <li>
 Design and implement advanced analytics solutions to support commerce data platform initiatives including analytics based on Machine Learning Models.
 </li>
 <li>
 Partner with engineering and product teams to define data requirements and ensure high-quality data pipelines.
 </li>
 <li>
 Conduct exploratory data analysis, feature engineering, and model evaluation using structured and unstructured datasets.
 </li>
 <li>
 Ensure the models built are operable, scalable, extensible and performant.
 </li>
 <li>
 Develop dashboards, visualizations, and storytelling artifacts to communicate insights to stakeholders.
 </li>
 <li>
 Lead experimentation efforts to evaluate new features, forecasting, data quality and anomaly detection systems.
 </li>
 <li>
 Build extensible solutions on LLM models to improve productivity of engineers across the commerce organization.
 
 
 </li>
 </ul>
 
 Qualifications
 
 
 
 <ul>
 <li>
 Bachelor&rsquo;s or Master&rsquo;s degree in Computer Science, Statistics, Mathematics, or related field.
 </li>
 <li>
 2+ years of experience in data science, analytics, or applied machine learning.
 </li>
 <li>
 Proficiency in Python, SQL, and ML frameworks (e.g., Scikit-learn, TensorFlow, PyTorch).
 </li>
 <li>
 Experience with cloud platforms (Azure preferred) and big data technologies.
 </li>
 <li>
 Strong understanding of statistical modeling, predictive analytics, and experimentation design.
 </li>
 <li>
 Excellent communication and stakeholder management skills.
 </li>
 <li>
 Demonstrated experience leveraging AI tools and technologies to enhance engineering effectiveness, coupled with a strong curiosity and commitment to continuous learning in the field of Artificial Intelligence.
 
 
 </li>
 </ul>
 This position will be open for a minimum of 5 days, with applications accepted on an ongoing basis until the position is filled.
 
 
 Microsoft is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to age, ancestry, citizenship, color, family or medical care leave, gender identity or expression, genetic information, immigration status, marital status, medical condition, national origin, physical or mental disability, political affiliation, protected veteran or military status, race, ethnicity, religion, sex (including pregnancy), sexual orientation, or any other characteristic protected by applicable local laws, regulations and ordinances. If you need assistance with religious accommodations and/or a reasonable accommodation due to a disability during the application process, read more about
 
 requesting accommodations.
 
</div>

Data Science Engineer

Cyient

<div>
 <ul>
 <li>
 Should have real time work experience of 2 to 4 years
 <ul>
 <li>
 Part Design
 </li>
 <li>
 Drafting&nbsp; as per ASME std.
 </li>
 <li>
 Well knowledge on manufacturing drawings
 </li>
 <li>
 Knowledge in Design
 </li>
 <li>
 Product Manufacturing process Knowledge is an added advantage
 </li>
 <li>
 Aero domain , UG and QN experience added advantage
 </li>
 <li>
 Geometric Dimension and Tolerances (GD &amp; T) Knowledge
 </li>
 <li>
 Good Communication skills&nbsp;
 </li>
 </ul>
 </li>
 </ul>
</div>

Aero Component Engineer

Explore 38+ Principal scientist t cell immunology in Hyderabad this December. Find roles across top companies and apply now to boost your career.