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Senior Research Associate

Department Overview:

The laboratory of Brian Scottoline at the Pape Family Pediatric Research Institute, is locaed in the Department of Pediatrics. In conjunction with the adjacent and collaborating laboratory of Sarah Andres we investigate the roles of human milk beyond nutrition, specifically, the impacts of human milk on intestinal epithelial cell biology, and the mechanisms of those interactions. We are particularly interested in how human milk reduces the risk for the devastating neonatal intestinal inflammatory disease, necrotizing enterocolitis. We are at the forefront of human milk research, using rare patient digrsted milk samples and, patient-derived intestinal organoids to investigate these questions.

Function/Duties of Position:

We are looking for a dynamic, organized, self-starter with a PhD or Masters degree with experience to help us make new discoveries. A strong candidate with a BS degree in Biology or Chemsitry with extensive researchexperience may also be considered.

The Senior Research Associate is responsible for executing, and overseeing complex organoid experiments and developing functional assays to delineate mechanisms of human milk action on intestinal development and maturation. This involves generating neonatal patient-derived intestinal organoids (enteroids) from surgical tissue samples. Cultivating enteroids requires keen attention to detail and impecable sterile technique.

The Senior Research Associate is also responsible the handling and purification of milk samples for exploring the physiology of milk interactions with intestinal epithelium, and for running various downstream cellular and molecular analyses including, qPCR, western blotting, immunostaining, advanced imaging, proteomics, and transcriptomics.

The position also requires the ability to develop new or optimize existing bioassays. The ability to manage multiple co-occuring experiments is essential. In addition to primary project responsibilitoes, this position may assist lab team members with experiments involving neonatal mouse models of the neonatal intestinal inflammatory disease necrotizing enterocolitis, and support for collaborating labs with visting members.

Required Qualifications:

PhD in relevant field AND 1 year of relevant experience OR Master's Degree in relevant field AND 5 years of relevant experience OR Bachelor's Degree in relevant field AND 9 years of relevant experience.
Working as part of a team
Working independently
Working in dynamic, stimulating environment
Dynamic
Organized
Self-starter
Willing to learn new skills
Flexible
Good time management
Ability to multitask
Strong oral and written communication skills
Strong problem solving skills
Detail oriented
Inquisitive
Persistent

Preferred Qualifications:

Degree in life sciences
Biomedical research laboratory experience
Molecular biology
Biochemistry
Cell culture techniques
Sterile technique
Bioinformatic experience
Microscopy
Immunostaining

Additional Details:

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Why apply to OHSU?: We are Oregon's only public academic health center. In addition to caring for patients, we lead groundbreaking research. We also train the next generation of health care professionals. As Portland's largest employer, we give you opportunities to learn and advance in a system of hospitals and clinics across Oregon and Southwest Washington. All are welcome. OHSU welcomes people of all ages, ethnicities, genders, national origins, religions and sexual orientations. We are striving to build an anti-racist, multicultural institution and encourage people with diverse backgrounds to apply. To request reasonable accommodation, contact askhr@ohsu.edu

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