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Senior Research Associate, Biology

About C4 Therapeutics:

C4 Therapeutics (C4T) (Nasdaq: CCCC) is a clinical-stage biopharmaceutical company dedicated to delivering on the promise of targeted protein degradation science to create a new generation of medicines that transforms patients’ lives. C4T is progressing targeted oncology programs through clinical studies and leveraging its TORPEDO® platform to efficiently design and optimize small-molecule medicines to address difficult-to-treat diseases. C4T’s degrader medicines are designed to harness the body’s natural protein recycling system to rapidly degrade disease-causing proteins, offering the potential to overcome drug resistance, drug undruggable targets and improve patient outcomes. For more information, please visit www.c4therapeutics.com.

Job Summary

We are seeking a highly motivated and detail-oriented Senior Research Associate to join our Discovery Biology team. The successful candidate will contribute to the discovery and development of novel targeted protein degraders for the treatment of autoimmune and neuroinflammatory diseases. You will be responsible for execution of in vitro and ex vivo experiments, with a strong emphasis on working with primary human immune cells. This is a hands-on, lab-based role where your contributions directly shape the next generation of immunotherapy.

Your Role

Design, execute, and analyze in vitro and ex vivo assays using primary human cells (e.g., PBMCs, monocytes, B cells, T cells, fibroblasts, neurons, etc.).
Perform flow cytometry, ELISA, cytokine profiling, and other immunoassays to assess compound activity and mechanism of action.
Isolate and culture primary human cells from blood samples or other suitable sources.
Collaborate closely with cross-functional teams including lead discovery, chemistry, and translational science to support program goals.
Maintain accurate and detailed experimental records in electronic lab notebooks.
Communicates data and findings in a clear/concise manner in team meetings and contributes to scientific discussions.

Your Background

Required:

A Bachelor’s Degree in Immunology, Cell Biology, or a related field with a minimum of four years of relevant post-graduate laboratory experience, including direct experience with primary human immune cell isolation, culture, and functional assays.
Experience working with autoimmune or neuroinflammatory disease models or patient-derived samples.
Experience with in vitro cell stimulation assays and functional readouts, as well as proficiency in multicolor flow cytometry and other immunological techniques such as ELISA, MSD, qPCR, and western blotting.
Proficiency in software such as PowerPoint, Word, GraphPad, FlowJo, etc., for data analysis, figure generation, and presentation.

Preferred:

Advanced Scientific Degree in a relevant discipline
Experience in a biotech or pharmaceutical setting is a plus.

Compensation

The base pay range for this position at commencement of employment is expected to be between $101,706.00 and $112,412.00 annually; however, base pay offered may vary depending on multiple individualized factors, including job-related knowledge, skills, and experience.

C4 Therapeutics is an Equal Opportunity Employer.

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