Senior Scientist

Company Description

NextGen Tides is an innovative biotech startup focused on oligonucleotide and peptide synthesis, conjugation technologies, and next-gen modality services (ASO, siRNA, PMO, AOC, etc.). We are building a top-tier, flexible CRO/CDMO platform that enables discovery-to-preclinical workflows for pharma, biotech, and academic partners worldwide.

POSITION SUMMARY:

The Principal/Senior Scientist, Oligonucleotides will establish Analytical capability in

separation science, and characterization within NextGen Tides’s oligonucleotides

platform supporting synthesis group and customer’s requests. In this visible role, the

candidate will be responsible for the Analytical and Purification method development of

novel modified oligonucleotides multiple modalities including ASO, siRNA, PMO, and

ligand-oligo-conjugation leveraging high-throughput automation and screening

workflows. This individual will have direct experience with analysis, purification, and

analytics of oligonucleotides and nucleoside analogs, as well as demonstrated ability to

work as part of an integrated team on multiple projects. He/She will have in depth

experience in the field of oligonucleotide/peptide therapeutics with knowledge in

chemical structure search tools, purification instrumentation, and analysis methods

related to chemically modified oligonucleotides. He/She will interact with all levels of the

organization and take on substantial ownership within NextGen Tides’s scientific

function. The successful candidate will focus on Method Development and Analysis of

oligonucleotides, and analytical characterization of multiple modalities. Leading through

contributions at the bench, the selected candidate will serve as Lead Oligonucleotide

Scientist for Analytical Team.

Key Responsibilities

• Serve as the Lead Oligonucleotide Scientist in cross-functional teams with

accountability for oligos purification and analytical analysis.

• Take a leadership role in maintaining all aspects of analytical/ purification

instrumentation and operations in the oligonucleotide laboratory.

• Develop and maintain standard operating procedures (SOPs) for processing,

purification, and analytical characterization to ensure high-quality and

reproducible results.

• Establish and maintain high-throughput automation workflows to support small

and mid-scale purification and analysis of ASOs, siRNA, PMO, and ligand-oligo-

conjugation with routine and novel next generation amidite synthesis.

• Establish and routinely perform oligos purification using ÄKTA and analytical

characterization workflows.

• Troubleshoot, operate and oversee the interpretation of data from LC-MS as well

as analytical and preparative HPLC.

• Work closely with synthesis and bioconjugation chemists to develop a seamless

workflow to support manufacturing of novel targeting ligands (e.g., peptide,

antibody, etc).

• With the growth of NextGen Tides, train and/or build a small team of research

associates to support oligos purification and analytical analysis capabilities.

• supervise and/or lead associates in a cross functional team environment.
• Demonstrate excellent written and verbal communication skills.
• Convey novel innovations at the project team level.

Qualifications & Experience

• A doctorate degree in Chemistry, Chemical Biology, Organic/Medicinal

Chemistry, or a related field.

• A minimum of 3+ (Senior Scientist) or 6+ (Principal Scientist) years of firsthand

industry experience in modern synthetic chemistry methods particularly in

nucleosides, nucleotides, and oligonucleotide synthesis, purification, and

analysis in pharmaceutical or biotechnology settings.

• Direct experience setting up and operating different instruments used in

oligonucleotides purification (e.g., ÄKTA Avant/Pure with Unicorn Software,

tangential flow filtration), analysis (e.g., UPLC, LC/MS, LC/HRMS), and

lyophilizes.

• A dependable contributor to cross-functional teams who embrace a collaborative

culture while demonstrating the autonomy and initiative required to deliver on

assigned scientific and operational responsibilities.

• Demonstrated ability to troubleshoot instrumentation and complex scientific

problems and adapt to shifting priorities in a fast-paced, quality-driven

environment.

• Prior experience in discovery of therapeutic oligonucleotides is highly desirable.

Compensation&Benefits

• Competitive base salary + commission
• Equity incentives for high performers
• 401(k) with employer contribution
• Health benefits and family medical coverage
• Vacation & PTO policy
• Opportunities to grow into principle/VP