Natural Products Scientist II

Natural Products Scientist II

Job ID: req4384
Employee Type: exempt full-time
Division: Applied & Development Research Program
Facility: Frederick: Ft Detrick
Location: PO Box B, Frederick, MD 21702 USA

The Frederick National Laboratory is operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.

PROGRAM DESCRIPTION

The Frederick National Laboratory for Cancer Research (FNLCR) is a Federally Funded Research and Development Center sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. With more than 2,000 employees, the FNLCR is responsible for pursuing its public health service mission via translational and applied biomedical research that is unique from academia, the pharmaceutical industry, or other federal contractors. There are excellent opportunities and support for collaborative research programs within the FNLCR and between the FNLCR and the NCI in developmental therapeutics, pharmacology, cancer genomics, computational biology, preclinical imaging, natural products, veterinary oncology, and solid and hematological malignancies and their preclinical models (including rare diseases and early passage patient-derived models). Outstanding core laboratories and an unparalleled environment for collaborations among basic, translational, and clinical scientists foster interdisciplinary research and translation of discoveries from the lab into the clinic. The selected candidate will join the Natural Products Support Group located at the NCI-Frederick campus.

The Natural Products Support Group provides scientific and technical support to the Developmental Therapeutics Program (DTP) of the NCI Division of Cancer Treatment and Diagnosis (DCTD), aiming to promote drug discovery from natural products, including those from the NCI Program for Natural Products Discovery (NPNPD). The group comprises several laboratories responsible for various natural product-based activities, including extracting plant, microbial, and marine biota; pre-fractionating and plating natural product extracts; isolating and identifying biologically active natural products; cryopreservation and microbial fermentations; and preparing drugs for in vitro and in vivo studies.

KEY ROLES/RESPONSIBILITIES

• Isolation and structure elucidation of natural products identified in high-throughput screens.
• Methods development towards the dereplication of the active principles from natural product fractions.
• Managing a nuclear magnetic resonance (NMR) facility.
• Generating reports and publications in the areas of isolation and structural elucidation of natural products from marine, microbial, and plant sources using state-of-the-art techniques.
• Maintaining chemistry laboratory instrumentation, including liquid chromatography systems and mass spectrometers.

BASIC QUALIFICATIONS

To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

• Possession of a Doctoral degree in chemistry, pharmacology, or a related discipline from an accredited college or university according to the Council for Higher Education Accreditation (CHEA). Foreign degrees must be evaluated for U.S. equivalency.
• In addition to the education requirement, a minimum of two (2) years experience with an emphasis in the isolation and structural elucidation of natural products.
• Demonstrated proficiency in the use of NMR instrumentation and data interpretation.
• Experience in managing an NMR facility, including troubleshooting, maintenance, user training, and support.
• Demonstrated publication record in the field of natural products chemistry.
• Experience isolating active compounds from diverse natural product extract libraries derived from plants, marine invertebrates, and microbes.
• Using modern spectroscopic analytical techniques to isolate and characterize complex organic molecules from natural product extracts.
• Ability to work in a team environment.
• Ability to obtain and maintain a security clearance.

PREFERRED QUALIFICATIONS

Candidates with these desired skills will be given preferential consideration:

• A minimum of five (5) years of post-graduate experience

Commitment to Non-Discrimination
All qualified applicants will receive consideration for employment without regard to sex, race, ethnicity, color, age, national origin, citizenship, religion, physical or mental disability, medical condition, genetic information, pregnancy, family structure, marital status, ancestry, domestic partner status, sexual orientation, gender identity or expression, veteran or military status, or any other basis prohibited by law. Leidos will also consider for employment qualified applicants with criminal histories consistent with relevant laws.

Pay and Benefits

Pay and benefits are fundamental to any career decision. That's why we craft compensation packages that reflect the importance of the work we do for our customers. Employment benefits include competitive compensation, Health and Wellness programs, Income Protection, Paid Leave and Retirement. More details are available here

103,100.00 - 172,625.00 USD

The posted pay range for this job is a general guideline and not a guarantee of compensation or salary. Additional factors considered in extending an offer include, but are not limited to, responsibilities of the job, education, experience, knowledge, skills, and abilities as well as internal equity, and alignment with market data.

The salary range posted is a full-time equivalent salary and will vary depending on scheduled hours for part time positions