Postdoctoral Fellow-MSH-12600-140

Details of Research Project: Postdoctoral fellowship focused on projects to reduce the burden of global cardiovascular disease, by designing and performing randomized clinical trials. The aim of the research team is to reduce the future risk of obesity, heart attacks, strokes and type 2 diabetes, as well as address atrial fibrillation and other common cardiovascular comorbidities. To ensure this, the fellow will leverage data from various large randomized clinical trials that are being designed/ongoing in the Institution and will deepen his knowledge on research methodology, cardiovascular clinical trials design and manuscript preparation for high-impact journals. The two main ongoing trials are the PRECAD and the reintervention trial for the FAMILIA cohort (FAMILIA-REUNION), in which the fellow will play an active role in the design, organization and scientific curation.

Technical Duties: (include any protocols)

• Assisting in the design and follow-up of randomized clinical trials.
• Assessing the health promotion interventions.
• Guaranteeing data protection and compliance with data protection and transfer laws.
• Devising plans for and assessing the participants involved in the study.
• Managing research data; helping to reply to queries related to the institutions financing the research projects, requesting program updates.
• Preparing publications for submission to high-impact journals.
• Organizing and giving presentations.
• Collaborating in subsidy applications for the different projects

Educational and other Requirements for the position:

The position requires a candidate with a minimum of four years of research experience, ideally in clinical or translational cardiovascular research. A strong background in clinical trial coordination, advanced imaging techniques, and data analysis is essential. Familiarity with LDL-lowering therapies and cardiovascular prevention strategies will be highly valued. The candidate should also demonstrate competence in scientific writing and communication, and have experience working in interdisciplinary and international research environments. Training in Good Clinical Practice (GCP) and the ability to manage multi-center studies are considered important assets for successful performance in this role.

Experience Required:

Applicants must have at least four years of hands-on experience in biomedical or clinical research, preferably within the field of cardiovascular prevention or lipid metabolism. Experience with electronic data capture systems, regulatory documentation, and image-based analysis of atherosclerosis (e.g., 3D vascular ultrasound) will be critical. The candidate should also be comfortable working in collaborative international teams and coordinating with multiple study sites. Previous publications, leadership in sub-studies, or participation in multicenter research consortia will be considered strong indicators of preparedness for this position

Goals/Outcomes of the Research Project:

The PRECAD clinical trial aims to assess the long-term benefits of early, intensive LDL-cholesterol lowering in young adults at high cardiovascular risk. The primary goal is to compare the progression of atherosclerotic plaque volume over five years using 3D vascular ultrasound between patients receiving standard care and those undergoing intensive intervention, including inclisiran. Secondary objectives include evaluating major cardiovascular events, changes in lipid profiles, and treatment adherence. Exploratory analyses will focus on biomarkers, cumulative LDL exposure, and subgroup effects (e.g., familial hypercholesterolemia). This research seeks to inform future clinical guidelines and shift preventive strategies to younger populations.

The reintervention in the FAMILIA cohort (FAMILIA-REUNION) is expected to improve health literacy and habits in the short and medium term. In the longer follow-up, objective endpoints such as blood biomarkers will be assessed. The researcher will engage in other projects proposed by his supervisor as well.

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Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

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Compensation

The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.