Sr. Scientist RNA Tx CGM

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Biological Research

Job Category:

Scientific/Technology

All Job Posting Locations:

San Diego, California, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com/.

An internal pre-identified candidate for consideration has been identified. However, all applications will be considered.

We are searching for the best talent for a Sr. Scientist RNA Tx CGM to be in San Diego, CA.

Position Summary

Scientific position within the Assay Development and Screening team developing assays to characterize oligonucleotides for target gene knockdown in relevant cell types, assess cell viability, screening for innate immune responses, and adapting assays to automation for high throughput screening of oligo libraries to identify hits and further characterize for potency and safety. Additionally, this position will provide analysis for PK/PD studies to test for siRNA levels and target mRNA levels in tissue samples.

You will be responsible for:

• Develop methods for RNA extraction, qPCR, immunoassays, and analytical methods to characterize oligonucleotides

• Conduct and troubleshoot experiments, independently and in collaboration with colleagues, to characterize and screen siRNA oligonucleotides through routine and consistent performance of 4 or more assays.

• Work with complex cell types including IPSC neurons for culturing and developing cell based functional assays

• Collect and evaluate data; prepare reports, summaries, and presentations; maintain and update laboratory notebook and the laboratory information management system

• Represent the ADS group on drug discovery project teams to plan for assay development and screening needs and updating the project team with resulting data, conclusions, and recommendations.

• Share work at team meetings and scientific forums for broader dissemination of results and contributions.

• Research literature and broaden scientific knowledge on relevant assay formats and disease areas, and strengthen expertise in oligo therapies.

• Support ADS team on operational lab functions, including managing inventories of supplies, ordering reagents and consumables

• Other activities may include serving as EH&S representative, DDI Champion, CREDO team member, or some other support role that helps the broader team.

Qualifications/Requirements:

Required:

• A Bachelor’s degree in Biology or related scientific field

• A minimum of 1 year in Complex cellular assays including primary cells and IPSC cells such as human neurons; Liquid handling automation; RNA extraction from cell cultures and tissues; QPCR, immunoassays; presentation skills; data analysis software such as Excel and Prism.

Preferred:

• Cell line generation; experience working with LIMS or databases; experience on cross functional matrix teams

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (ra-employeehealthsup@its.jnj.com) or contact AskGS to be directed to your accommodation resource.

The anticipated base pay range for this position is :

The anticipated base pay range for this position is $105,000 to $169,050 annually.

Additional Description for Pay Transparency:

· The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation’s performance over a calendar/performance year. Bonuses are awarded at the Company’s discretion on an individual basis. · Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance. · Employees may be eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)). · Employees are eligible for the following time off benefits: o Vacation – up to 120 hours per calendar year o Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington – up to 56 hours per calendar year o Holiday pay, including Floating Holidays – up to 13 days per calendar year of Work, Personal and Family Time - up to 40 hours per calendar year · Additional information can be found through the link below. https://www.careers.jnj.com/employee-benefits The compensation and benefits information set forth in this posting applies to candidates hired in the United States. Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market.